Department of Biology, University of Toronto Mississauga, Ontario, Canada.
Department of Cell & Systems Biology, University of Toronto, Ontario, Canada.
Trends Pharmacol Sci. 2023 Oct;44(10):664-673. doi: 10.1016/j.tips.2023.08.001. Epub 2023 Aug 31.
Psychedelic drugs have experienced an unprecedented surge in recreational use within the past few years. Among recreational users, the risks of psychedelic use by pregnant and breastfeeding women are severely understudied and there is little information on the potential teratogenic effects of these drugs. We provide an overview of the previous data on psychedelic teratogenicity from rodent studies and human surveys, discuss their limitations, and propose the utility of the zebrafish as a potential effective model for investigating psychedelic teratogenicity. Recent years have validated the use of zebrafish in the study of fetal exposure and developmental biology; we highlight these properties of the zebrafish for its suitability in psychedelic toxicity research.
迷幻药物在过去几年中的娱乐用途经历了前所未有的激增。在娱乐性使用者中，孕妇和哺乳期妇女使用迷幻药物的风险严重研究不足，关于这些药物潜在致畸作用的信息也很少。我们提供了来自啮齿动物研究和人类调查的迷幻致畸性的先前数据概述，讨论了它们的局限性，并提出了使用斑马鱼作为研究迷幻致畸性的潜在有效模型的实用性。近年来，斑马鱼在胎儿暴露和发育生物学研究中的应用已得到验证；我们强调了斑马鱼的这些特性，因为它适合迷幻毒性研究。
