Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Hengyang Medical School, Cancer Research Institute, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.
Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.
Clin Exp Med. 2023 Dec;23(8):4449-4456. doi: 10.1007/s10238-023-01178-y. Epub 2023 Sep 2.
Angiopoietin4(ANGPT4) which plays a significant role in endothelial cell proliferation, survival, angiogenesis and expansion in tumors and other pathological states is a significant regulator of tumor angiogenesis. ANGPT4 expression is enhanced in many cancer cells. For example, the overexpression of ANGPT4 promotes the formation, development and progress of lung adenocarcinoma, glioblastoma and ovarian cancer. Related studies show that ANGPT4 encourages the proliferation, survival and invasion of tumor cells, while promoting the expansion of the tumor vascular system and affecting the tumor immune microenvironment. ANGPT4 can also promote carcinogenesis by affecting the ERK1/2, PI3K/AKT and other signal pathways downstream of tyrosine kinase with immunoglobulin-like and EGF-like domains 2(TIE2) and TIE2. Therefore, ANGPT4 may be a potential and significant biomarker for predicting malignant tumor progression and adverse outcomes. In addition, inhibition of ANGPT4 may be a meaningful cancer treatment. This paper reviews the latest research results of ANGPT4 in preclinical research, and emphasizes its role in carcinogenesis. Additional research on the carcinogenic function of ANGPT4 could provide new insights into cancer biology and novel methods for cancer diagnosis and treatment.
血管生成素 4（ANGPT4）在肿瘤和其他病理状态下的内皮细胞增殖、存活、血管生成和扩张中起着重要作用，是肿瘤血管生成的重要调节剂。ANGPT4 在许多癌细胞中的表达增强。例如，ANGPT4 的过表达促进肺腺癌、胶质母细胞瘤和卵巢癌的形成、发展和进展。相关研究表明，ANGPT4 促进肿瘤细胞的增殖、存活和侵袭，同时促进肿瘤血管系统的扩张，并影响肿瘤免疫微环境。ANGPT4 还可以通过影响酪氨酸激酶免疫球蛋白样和表皮生长因子样结构域 2（TIE2）和 TIE2 下游的 ERK1/2、PI3K/AKT 等信号通路促进致癌作用。因此，ANGPT4 可能是预测恶性肿瘤进展和不良结局的一个有潜力和重要的生物标志物。此外，抑制 ANGPT4 可能是一种有意义的癌症治疗方法。本文综述了 ANGPT4 在临床前研究中的最新研究成果，并强调了其在致癌作用中的作用。对 ANGPT4 致癌功能的进一步研究可为癌症生物学提供新的见解，并为癌症的诊断和治疗提供新的方法。
