Department of Evidence-Based Medicine, Southwest Medical University, China.
Department of Evidence-Based Medicine, Southwest Medical University, China.
Int Immunopharmacol. 2020 Mar;80:106223. doi: 10.1016/j.intimp.2020.106223. Epub 2020 Jan 25.
Angiogenesis is defined as the growth of new capillaries sprouting from pre-existing vasculature. Pathological angiogenesis signals can lead to dysregulated development of new vessels. Inflammation is accompanied by pathological angiogenesis. During an inflammatory process, newly formed blood vessels provide oxygen and nutrients to the inflamed tissue, facilitating the transport of inflammatory cells. Therefore, angiogenesis is closely related to pathogenesis of inflammatory autoimmune diseases. As a member of the angiopoietin family, Angiopoietin-2 (Ang-2) plays an irreplaceable role in angiogenesis. This review will narrate the expression of Ang-2 and its role in inflammatory autoimmune diseases. Collecting this information may improve the acquaintance of Ang-2 and provide a theoretical foundation for clinical trials and drug development in the future.
血管生成被定义为新的毛细血管从预先存在的脉管系统中生长出来。病理性血管生成信号可导致新血管的失调发育。炎症伴随着病理性血管生成。在炎症过程中，新形成的血管为炎症组织提供氧气和营养物质，促进炎症细胞的运输。因此，血管生成与炎症性自身免疫性疾病的发病机制密切相关。作为血管生成素家族的一员，血管生成素-2（Ang-2）在血管生成中起着不可替代的作用。本综述将叙述 Ang-2 的表达及其在炎症性自身免疫性疾病中的作用。收集这些信息可能有助于提高对 Ang-2 的认识，并为未来的临床试验和药物开发提供理论基础。
