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早产儿肿瘤溶解综合征促使早期切除巨大骶尾部畸胎瘤：病例报告。

Tumor lysis syndrome in premature infant prompting early resection of a large sacrococcygeal teratoma: a case report.

机构信息

Maternal Fetal Neonatal Institute, Johns Hopkins All Children's Hospital, Florida, USA.

Department of Obstetrics and Gynecology, Bayfront Medical Center, Orlando Health, Florida, USA.

出版信息

BMC Pediatr. 2023 Sep 2;23(1):440. doi: 10.1186/s12887-023-04193-w.

DOI:10.1186/s12887-023-04193-w
PMID:37660010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10474622/
Abstract

BACKGROUND

Sacrococcygeal teratomas (SCTs) are the most common congenital neoplasm and often require resection soon after birth. There are rare reports of cardiac arrest during surgery due to manipulation of the tumor triggering secondary necrosis and hyperkalemia.

CASE PRESENTATION

This case describes a very preterm infant with a SCT who develops spontaneous preoperative tumor lysis syndrome (TLS). The medical team utilized rasburicase and the patient underwent total gross resection at 40 h of life.

CONCLUSIONS

We emphasize the importance of the early recognition and management of tumor lysis syndrome in SCT with rasburicase, aggressive management of hyperkalemia and consideration of early resection of SCTs even in the case of a very premature infant.

摘要

背景

骶尾部畸胎瘤（SCT）是最常见的先天性肿瘤，通常需要在出生后不久进行切除。由于肿瘤的操作引发继发性坏死和高钾血症，手术中发生心脏骤停的罕见报告。

病例介绍

本病例描述了一例患有 SCT 的极早产儿，其术前发生自发性肿瘤溶解综合征（TLS）。医疗团队使用了拉布立酶，患儿在出生后 40 小时进行了肿瘤全切除。

结论

我们强调了在 SCT 中使用拉布立酶早期识别和管理肿瘤溶解综合征的重要性，积极管理高钾血症，并考虑即使是极早产儿也应尽早切除 SCT。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d04/10474622/bc20d5bde993/12887_2023_4193_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d04/10474622/fae9436ebe34/12887_2023_4193_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d04/10474622/85285f820060/12887_2023_4193_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d04/10474622/bf96943aa58e/12887_2023_4193_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d04/10474622/6cc00f235036/12887_2023_4193_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d04/10474622/46178b7d58c4/12887_2023_4193_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d04/10474622/a2649c63f185/12887_2023_4193_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d04/10474622/bc20d5bde993/12887_2023_4193_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d04/10474622/fae9436ebe34/12887_2023_4193_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d04/10474622/85285f820060/12887_2023_4193_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d04/10474622/bf96943aa58e/12887_2023_4193_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d04/10474622/6cc00f235036/12887_2023_4193_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d04/10474622/46178b7d58c4/12887_2023_4193_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d04/10474622/a2649c63f185/12887_2023_4193_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d04/10474622/bc20d5bde993/12887_2023_4193_Fig7_HTML.jpg

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