Department of System Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, 40002, Thailand.
Recent Results Cancer Res. 2023;219:53-90. doi: 10.1007/978-3-031-35166-2_4.
Cholangiocarcinoma (CCA) is a malignant tumor of the biliary tree that is classified into three groups based on its anatomic location: intrahepatic (iCCA), perihilar (pCCA), and distal (dCCA). Perihilar CCA is the most common type and accounts for 50-60% of CCA cases. It is followed by distal CCA and then intrahepatic CCA that account for 20-30% and 10-20% of cases, respectively. This chapter discusses the hallmarks of liver fluke related CCA and explores insights into drug target possibilities.
胆管癌（CCA）是一种源于胆道的恶性肿瘤，根据其解剖位置可分为三组：肝内（iCCA）、肝门周围（pCCA）和远端（dCCA）。肝门周围 CCA 最常见，占 CCA 病例的 50-60%。其次是远端 CCA，然后是肝内 CCA，分别占 20-30%和 10-20%。本章讨论了与肝吸虫相关的 CCA 的特征，并探讨了药物靶点的可能性。
