Kepes J J, Dunlap M D, O'Boynick P, Terreros D
Acta Neuropathol. 1986;70(3-4):314-9. doi: 10.1007/BF00686090.
A case of a left tentorial meningioma in a 42-year-old man with a 12-year history of widespread manifestations of active rheumatoid arthritis, is reported. The patient had numerous subcutaneous rheumatoid nodules involving among other areas, the nuchal scalp. The surgically removed meningioma contained many classical rheumatoid nodules with gradual transitions seen from tumor cells to the pallisading peripheral cell layer of the nodules. Although intracranial rheumatoid nodules of the dura mater, leptomeninges, and of the choroid plexus have been described earlier, this appears to be the first reported case of rheumatoid nodules found within the substance of a meningioma. The participation of the tumor cells in the formation of rheumatoid nodules attests to the potential of neoplastic meningothelial cells to behave as mesenchymal elements under certain circumstances.
报告了一例42岁男性左小脑幕脑膜瘤病例，该患者有12年活动性类风湿关节炎广泛表现的病史。患者有许多皮下类风湿结节，累及包括颈后头皮在内的其他部位。手术切除的脑膜瘤包含许多典型的类风湿结节，可见从肿瘤细胞到结节栅栏状外周细胞层的逐渐过渡。尽管先前已描述过硬脑膜、软脑膜和脉络丛的颅内类风湿结节，但这似乎是首次报道在脑膜瘤实质内发现类风湿结节的病例。肿瘤细胞参与类风湿结节的形成证明了肿瘤性脑膜内皮细胞在某些情况下具有间充质成分的潜能。
