KIF4 Gene Variant's Disruption of PARP1 Signaling Increases Anxiety and Seizure Susceptibility.
作者信息
Bordey Angelique
机构信息
Departments of Neurosurgery, and Cellular & Molecular Physiology, Yale School of Medicine.
出版信息
Epilepsy Curr. 2023 May 22;23(4):257-258. doi: 10.1177/15357597231175007. eCollection 2023 Jul-Aug.
Abstract
摘要
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本文引用的文献
1
KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.KIF4 通过 PARP1 信号通路调节神经元形态和癫痫易感性。
J Cell Biol. 2023 Feb 6;222(2). doi: 10.1083/jcb.202208108. Epub 2022 Dec 8.
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Filamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations.细丝蛋白A抑制可降低局灶性皮质发育异常小鼠模型中的癫痫发作活动。
Sci Transl Med. 2020 Feb 19;12(531). doi: 10.1126/scitranslmed.aay0289.
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The multiple functions of kinesin-4 family motor protein KIF4 and its clinical potential.驱动蛋白-4 家族运动蛋白 KIF4 的多种功能及其临床潜力。
Gene. 2018 Dec 15;678:90-99. doi: 10.1016/j.gene.2018.08.005. Epub 2018 Aug 3.
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PARP1 orchestrates epigenetic events setting up chromatin domains.PARP1 调控组蛋白事件，建立染色质结构域。
Semin Cell Dev Biol. 2017 Mar;63:123-134. doi: 10.1016/j.semcdb.2016.11.010. Epub 2016 Nov 28.
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Involvement of the kinesin family members KIF4A and KIF5C in intellectual disability and synaptic function.驱动蛋白家族成员KIF4A和KIF5C与智力障碍及突触功能的关系。
J Med Genet. 2014 Jul;51(7):487-94. doi: 10.1136/jmedgenet-2013-102182. Epub 2014 May 8.
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Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.神经元中的分子马达：在大脑功能、发育和疾病中的运输机制和作用。
Neuron. 2010 Nov 18;68(4):610-38. doi: 10.1016/j.neuron.2010.09.039.
7
KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity.驱动蛋白4通过抑制聚（ADP-核糖）聚合酶-1的酶活性来调节活性依赖的神经元存活。
Cell. 2006 Apr 21;125(2):371-83. doi: 10.1016/j.cell.2006.02.039.
8
Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization.通过原位杂交将驱动蛋白家族成员4基因（KIF4A和KIF4B）定位到人类染色体带Xq13.1和5q33.1。
Cytogenet Cell Genet. 2000;88(1-2):41-2. doi: 10.1159/000015482.
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