格鲁吉亚门诊患者中乙肝疫苗的血清转化情况。

Seroconversion of hepatitis B vaccine among patients from outpatient clinic in Georgia.

作者信息

Kanchelashvili Giorgi, Kamkamidze George, Davitadze Meri, Bzishvili Nino, Abzianidze Tinatin, Gulbiani Lasha, Butsashvili Maia

机构信息

Health Research Union, 8 Nutsubidze Street, 0177 Tbilisi, Georgia.

The University of Georgia, 77a Kostava Street, 0171 Tbilisi, Georgia.

出版信息

Vaccine X. 2023 Aug 22;15:100375. doi: 10.1016/j.jvacx.2023.100375. eCollection 2023 Dec.

DOI:10.1016/j.jvacx.2023.100375

PMID:37663048

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10474044/

Abstract

INTRODUCTION

Hepatitis B virus (HBV) is a serious global health challenge with vaccination being the most effective preventive measure. However, several risk-factors may impact HBV vaccine immunogenicity. We aimed to evaluate the immunogenicity of the HBV vaccine.

METHODS

Participants' socio-demographic data were obtained from medical records. Anti-HBs testing was performed. Descriptive and bivariate analyses were performed.

RESULTS

Among 431 participants, 62.2 % (n = 268) were males. In all, 43.2 % (n = 186) had normal weight, 24.8 % (n = 107) were overweight, and 17.6 % (n = 76) had obesity. Seroconversion after 3-dose HBV vaccination was 74.7 %. Participants with normal weight had higher seroprevalence (n = 156/186, 83.9 %), compared with those with overweight (n = 72/107, 67.3 %) or obesity (n = 48/76, 63.2 %) (Normal weight vs overweight: aOR = 2.44, 95 % CI: 1.38-4.32 and normal weight vs obesity: aOR = 2.97, 95 % CI:1.61-5.47).

CONCLUSION

BMI is an independent factor impairing the vaccine response. These findings urge for more tailored vaccination strategies with focus on higher risk populations.

摘要

引言

乙型肝炎病毒（HBV）是一项严峻的全球健康挑战，接种疫苗是最有效的预防措施。然而，若干风险因素可能会影响HBV疫苗的免疫原性。我们旨在评估HBV疫苗的免疫原性。

方法

从医疗记录中获取参与者的社会人口统计学数据。进行抗-HBs检测。进行描述性和双变量分析。

结果

在431名参与者中，62.2%（n = 268）为男性。总体而言，43.2%（n = 186）体重正常，24.8%（n = 107）超重，17.6%（n = 76）肥胖。3剂HBV疫苗接种后的血清转化率为74.7%。体重正常的参与者血清阳性率更高（n = 156/186，83.9%），高于超重者（n = 72/107，67.3%）或肥胖者（n = 48/76，63.2%）（体重正常与超重相比：调整后比值比 = 2.44，95%置信区间：1.38 - 4.32；体重正常与肥胖相比：调整后比值比 = 2.97，95%置信区间：1.61 - 5.47）。

结论

BMI是损害疫苗反应的独立因素。这些发现促使我们制定更具针对性的疫苗接种策略，重点关注高风险人群。

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格鲁吉亚门诊患者中乙肝疫苗的血清转化情况。

Seroconversion of hepatitis B vaccine among patients from outpatient clinic in Georgia.

作者信息

Kanchelashvili Giorgi, Kamkamidze George, Davitadze Meri, Bzishvili Nino, Abzianidze Tinatin, Gulbiani Lasha, Butsashvili Maia

机构信息

Health Research Union, 8 Nutsubidze Street, 0177 Tbilisi, Georgia.

The University of Georgia, 77a Kostava Street, 0171 Tbilisi, Georgia.

出版信息

Vaccine X. 2023 Aug 22;15:100375. doi: 10.1016/j.jvacx.2023.100375. eCollection 2023 Dec.

DOI:10.1016/j.jvacx.2023.100375

PMID:37663048

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10474044/

Abstract

INTRODUCTION

METHODS

Participants' socio-demographic data were obtained from medical records. Anti-HBs testing was performed. Descriptive and bivariate analyses were performed.

RESULTS

CONCLUSION

BMI is an independent factor impairing the vaccine response. These findings urge for more tailored vaccination strategies with focus on higher risk populations.

摘要

引言

方法

从医疗记录中获取参与者的社会人口统计学数据。进行抗-HBs检测。进行描述性和双变量分析。

结果

结论

BMI是损害疫苗反应的独立因素。这些发现促使我们制定更具针对性的疫苗接种策略，重点关注高风险人群。

格鲁吉亚门诊患者中乙肝疫苗的血清转化情况。

Seroconversion of hepatitis B vaccine among patients from outpatient clinic in Georgia.

作者信息

机构信息

出版信息

INTRODUCTION

METHODS

RESULTS

CONCLUSION

引言

方法

结果

结论

相似文献

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格鲁吉亚门诊患者中乙肝疫苗的血清转化情况。

Seroconversion of hepatitis B vaccine among patients from outpatient clinic in Georgia.

作者信息

机构信息

出版信息

INTRODUCTION

METHODS

RESULTS

CONCLUSION

引言

方法

结果

结论