格鲁吉亚门诊患者中乙肝疫苗的血清转化情况。

Seroconversion of hepatitis B vaccine among patients from outpatient clinic in Georgia.

作者信息

Kanchelashvili Giorgi, Kamkamidze George, Davitadze Meri, Bzishvili Nino, Abzianidze Tinatin, Gulbiani Lasha, Butsashvili Maia

机构信息

Health Research Union, 8 Nutsubidze Street, 0177 Tbilisi, Georgia.

The University of Georgia, 77a Kostava Street, 0171 Tbilisi, Georgia.

出版信息

Vaccine X. 2023 Aug 22;15:100375. doi: 10.1016/j.jvacx.2023.100375. eCollection 2023 Dec.

DOI:10.1016/j.jvacx.2023.100375

PMID:37663048

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10474044/

Abstract

INTRODUCTION

Hepatitis B virus (HBV) is a serious global health challenge with vaccination being the most effective preventive measure. However, several risk-factors may impact HBV vaccine immunogenicity. We aimed to evaluate the immunogenicity of the HBV vaccine.

METHODS

Participants' socio-demographic data were obtained from medical records. Anti-HBs testing was performed. Descriptive and bivariate analyses were performed.

RESULTS

Among 431 participants, 62.2 % (n = 268) were males. In all, 43.2 % (n = 186) had normal weight, 24.8 % (n = 107) were overweight, and 17.6 % (n = 76) had obesity. Seroconversion after 3-dose HBV vaccination was 74.7 %. Participants with normal weight had higher seroprevalence (n = 156/186, 83.9 %), compared with those with overweight (n = 72/107, 67.3 %) or obesity (n = 48/76, 63.2 %) (Normal weight vs overweight: aOR = 2.44, 95 % CI: 1.38-4.32 and normal weight vs obesity: aOR = 2.97, 95 % CI:1.61-5.47).

CONCLUSION

BMI is an independent factor impairing the vaccine response. These findings urge for more tailored vaccination strategies with focus on higher risk populations.

摘要

引言

乙型肝炎病毒（HBV）是一项严峻的全球健康挑战，接种疫苗是最有效的预防措施。然而，若干风险因素可能会影响HBV疫苗的免疫原性。我们旨在评估HBV疫苗的免疫原性。

方法

从医疗记录中获取参与者的社会人口统计学数据。进行抗-HBs检测。进行描述性和双变量分析。

结果

在431名参与者中，62.2%（n = 268）为男性。总体而言，43.2%（n = 186）体重正常，24.8%（n = 107）超重，17.6%（n = 76）肥胖。3剂HBV疫苗接种后的血清转化率为74.7%。体重正常的参与者血清阳性率更高（n = 156/186，83.9%），高于超重者（n = 72/107，67.3%）或肥胖者（n = 48/76，63.2%）（体重正常与超重相比：调整后比值比 = 2.44，95%置信区间：1.38 - 4.32；体重正常与肥胖相比：调整后比值比 = 2.97，95%置信区间：1.61 - 5.47）。