2型糖尿病患者C肽与外周动脉粥样硬化严重程度的相关性
The Correlation Between C-Peptide and Severity of Peripheral Atherosclerosis in Type 2 Diabetes Mellitus.
作者信息
Wahab Maisa A, Alhabibi Alshaymaa M, Sakr Ahmed Khairy, Zakaria Mohamed Yahia, Saleh Ola I, Ahmad Inass Hassan, Abdelrahman Eman Kamel, Taha Randa Sabour Elshahat, Ahmed Fayka Karem Abdel Azeem, Ismail Bothayna, Azel Lamiaa Hosney, Hassan Asmaa S, El Sayed Hanaa Mohammed Eid, Kasim Sammar Ahmed, Elsharkawy Safaa Abdelfattah
机构信息
Department of Vascular Surgery, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Department of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
出版信息
Diabetes Metab Syndr Obes. 2023 Aug 29;16:2617-2625. doi: 10.2147/DMSO.S426956. eCollection 2023.
BACKGROUND
One of the major issues affecting global health is Diabetes mellitus (DM), not only in terms of the disease itself but also its complications. Macrovascular complications are both common and serious, affecting many patients. This study aimed to assess fasting C-peptide levels and correlate them with the severity of the peripheral arterial disease complicating type 2 DM (T2DM).
PATIENTS AND METHODS
This study included 200 participants who were categorized into two groups: Group I (n=100, patients with T2DM complicated by femoropopliteal arterial atherosclerosis) and Group II (n=100, healthy age- and sex-matched individuals serving as controls). Fasting C-peptide levels were estimated using an immunochemiluminometric assay.
RESULTS
Fasting C-peptide levels were significantly higher in Group I than in the control group. Fasting C-peptide levels were positively correlated with the severity of atherosclerosis. In addition, the receiver operating characteristic (ROC) curve analysis revealed that fasting C-peptide levels served as a specific and sensitive marker for detecting the severity of this disease.
CONCLUSION
Fasting C-peptide levels can be used as a sensitive and specific indicator of the severity of femoropopliteal arteriosclerosis that complicates T2DM.
背景
糖尿病（DM）是影响全球健康的主要问题之一，不仅涉及疾病本身，还包括其并发症。大血管并发症常见且严重，影响众多患者。本研究旨在评估空腹C肽水平，并将其与2型糖尿病（T2DM）合并的外周动脉疾病的严重程度相关联。
患者与方法
本研究纳入200名参与者，分为两组：第一组（n = 100，患有股腘动脉粥样硬化合并T2DM的患者）和第二组（n = 100，年龄和性别匹配的健康个体作为对照）。使用免疫化学发光法测定空腹C肽水平。
结果
第一组的空腹C肽水平显著高于对照组。空腹C肽水平与动脉粥样硬化的严重程度呈正相关。此外，受试者工作特征（ROC）曲线分析显示，空腹C肽水平是检测该疾病严重程度的特异性和敏感性标志物。
结论
空腹C肽水平可作为T2DM合并股腘动脉硬化严重程度的敏感和特异性指标。
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