Van Der Veen Sterre, Tijssen Marina A J, Berkovic Samuel F
Department of Neurology (SVDV, MAJT), University of Groningen, University Medical Centre Groningen; Expertise Centre Movement Disorders Groningen (SVDV, MAJT), University Medical Centre Groningen; and Epilepsy Research Centre (SVDV, SFB), Department of Medicine, University of Melbourne, Austin Health.
Neurol Clin Pract. 2023 Oct;13(5):e200187. doi: 10.1212/CPJ.0000000000200187. Epub 2023 Aug 31.
Myoclonus is often approached in different ways by epileptologists and movement disorder specialists, leading to confusion in the literature. Multiplicity and inconsistency over the past 2 centuries resulted in a lack of precision and ambiguity of the terminology. We show that this is a current problem in which one phenomenon has been described with many terms and vice versa. Of more importance, we discuss the conceptualization of myoclonus from perspectives of both fields and focus on the borderland that exists, especially in the spectrum of cortical and epileptic myoclonus. By giving 2 examples, we illustrate the conundrum: the spectrum of progressive myoclonus epilepsies and progressive myoclonic ataxias and "cortical tremor" observed in familial cortical myoclonic tremor with epilepsy or familial adult myoclonic epilepsy. We attempt to facilitate to bridge these subspecialties and form the base for a uniform understanding to take this issue forward toward future classifications, discussions, and scientific research.
癫痫学家和运动障碍专家对肌阵挛的研究方式往往不同，这导致了文献中的混乱。在过去的两个世纪里，其多样性和不一致性导致了术语缺乏精确性和模糊性。我们表明，这是一个当前存在的问题，即一种现象用了许多术语来描述，反之亦然。更重要的是，我们从这两个领域的角度讨论肌阵挛的概念，并关注存在的边缘地带，特别是在皮质性和癫痫性肌阵挛的范围内。通过给出两个例子，我们说明了这一难题：进行性肌阵挛癫痫和进行性肌阵挛共济失调的范围，以及在家族性皮质肌阵挛震颤伴癫痫或家族性成人肌阵挛癫痫中观察到的“皮质震颤”。我们试图促进这些亚专业之间的沟通，为统一理解奠定基础，以便在未来的分类、讨论和科学研究中推进这一问题。
