Wang Jiajia, Wan Xichen, Le Qihua
Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
Research Center, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
Front Mol Biosci. 2023 Aug 17;10:1250530. doi: 10.3389/fmolb.2023.1250530. eCollection 2023.
SOX9, a member of the SRY-related HMG-box transcription factors, has been reported to critically regulate fetal development and stem cell homeostasis. Wnt signalling is a highly conserved signalling pathway that controls stem cell fate decision and stemness maintenance throughout embryonic development and adult life. Many studies have shown that the interactions between SOX9 and the canonical Wnt signalling pathway are involved in many of the physiological and pathological processes of stem cells, including organ development, the proliferation, differentiation and stemness maintenance of stem cells, and tumorigenesis. In this review, we summarize the already-known molecular mechanism of cross-interactions between SOX9 and the canonical Wnt signalling pathway, outline its regulatory effects on the maintenance of homeostasis in different types of stem cells, and explore its potential in translational stem cell therapy.
SOX9是SRY相关的HMG盒转录因子家族的成员，据报道它对胎儿发育和干细胞稳态起着关键的调节作用。Wnt信号通路是一条高度保守的信号通路，在整个胚胎发育和成年期控制干细胞的命运决定和干性维持。许多研究表明，SOX9与经典Wnt信号通路之间的相互作用参与了干细胞的许多生理和病理过程，包括器官发育、干细胞的增殖、分化和干性维持以及肿瘤发生。在这篇综述中，我们总结了SOX9与经典Wnt信号通路之间交叉相互作用的已知分子机制，概述了其对不同类型干细胞稳态维持的调节作用，并探讨了其在转化干细胞治疗中的潜力。
