Rasheed Abdul Hannan A, Zhang Xin, Liu Song, Picken Maria M, Vellanki Kavitha
Medicine/Nephrology, Loyola University Medical Center, Maywood, USA.
Pathology, Loyola University Medical Center, Maywood, USA.
Cureus. 2023 Aug 3;15(8):e42909. doi: 10.7759/cureus.42909. eCollection 2023 Aug.
Plasma cell leukemia (PCL) is a rare aggressive variant of plasma cell myeloma. The differential diagnosis of PCL includes multiple myeloma (MM), other leukemias, and lymphomas with abnormal cells circulating in the peripheral blood. In addition, infectious or autoimmune diseases can cause reactive polyclonal plasmacytosis, which could confuse us with PCL occasionally. Sometimes, blastoid morphology can cause confusion in diagnosis, and immunohistochemistry is needed to differentiate PCL from other forms of leukemias and lymphomas. Here, we present a rare case of PCL diagnosed as acute myeloid leukemia (AML) with kidney biopsy establishing the correct diagnosis.
浆细胞白血病（PCL）是浆细胞骨髓瘤的一种罕见侵袭性变体。PCL的鉴别诊断包括多发性骨髓瘤（MM）、其他白血病以及外周血中存在异常循环细胞的淋巴瘤。此外，感染性或自身免疫性疾病可导致反应性多克隆浆细胞增多症，偶尔会与PCL混淆。有时，母细胞样形态会导致诊断困难，需要免疫组织化学来区分PCL与其他形式的白血病和淋巴瘤。在此，我们报告一例罕见的PCL病例，最初被诊断为急性髓系白血病（AML），通过肾脏活检得以确立正确诊断。
