Shiffer Dana, Zamunér Antonio Roberto, Minonzio Maura, Bulgheroni Mara, Porta Alberto, Leone Roberto, Bottazzi Barbara, Garlanda Cecilia, Colotta Francesco, Barbic Franca, Mantovani Alberto, Furlan Raffaello
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Internal Medicine, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Front Physiol. 2023 Aug 16;14:1168652. doi: 10.3389/fphys.2023.1168652. eCollection 2023.
Systemic inflammation promotes neurodegeneration in Parkinson's disease (PD). Interleukin-1 receptor type 2 (sIL-1R2) plasma levels increase during inflammation. Data on sIL-1R2 in PD patients and its relationship with PD cardiac autonomic profile are limited, given the possible anti-inflammatory effect of vagal activation. Previously, automated mechanical peripheral somatosensory stimulation (AMPSS) enhanced cardiac vagal modulation. Objectives were to 1) evaluate sIL-1R2 plasma concentrations in PD patients and healthy controls and 2) investigate the correlations between sIL-1R2 and cardiac autonomic indices obtained by spectrum analysis of heart rate variability before and after AMPSS. sIL-1R2 plasma levels were assessed in 48 PD patients and 50 healthy controls. Electrocardiogram and beat-by-beat arterial pressure were recorded at baseline and after 5 AMPSS sessions in 16 PD patients. PD patients had higher sIL-1R2 levels than controls. In the PD subgroup, an inverse correlation between sIL-1R2 and HFnu was found. There was a negative correlation between changes induced by AMPSS on HFnu and sIL-1R2. Higher sIL-1R2 levels in PD patients reflect the inflammatory dysregulation associated with the disease. In PD patients, higher sIL-1R2 was associated with reduced cardiovagal tone. Increased cardiovagal modulation following AMPSS was associated with lower sIL-1R2 levels in Parkinson's disease patients, suggesting inflammatory state improvement.
全身炎症促进帕金森病（PD）中的神经退行性变。炎症期间白细胞介素-1受体2型（sIL-1R2）血浆水平升高。鉴于迷走神经激活可能具有的抗炎作用，关于PD患者中sIL-1R2及其与PD心脏自主神经特征的关系的数据有限。此前，自动机械性外周体感刺激（AMPSS）增强了心脏迷走神经调制。目的是：1）评估PD患者和健康对照者的sIL-1R2血浆浓度；2）研究sIL-1R2与AMPSS前后通过心率变异性频谱分析获得的心脏自主神经指标之间的相关性。对48例PD患者和50例健康对照者的sIL-1R2血浆水平进行了评估。在16例PD患者中，于基线和5次AMPSS疗程后记录心电图和逐搏动脉压。PD患者的sIL-1R2水平高于对照组。在PD亚组中，发现sIL-1R2与高频归一化值（HFnu）呈负相关。AMPSS对HFnu的诱导变化与sIL-1R2之间存在负相关。PD患者中较高的sIL-1R2水平反映了与该疾病相关的炎症失调。在PD患者中，较高的sIL-1R2与心脏迷走神经张力降低相关。AMPSS后心脏迷走神经调制增加与帕金森病患者较低的sIL-1R2水平相关，提示炎症状态改善。
