Copur Sidar, Peltek Ibrahim B, Mutlu Ali, Tanriover Cem, Kanbay Mehmet
Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.
Department of Medicine, Section of Nephrology, Koc University School of Medicine, Istanbul, Turkey.
Clin Kidney J. 2023 Mar 23;16(9):1403-1419. doi: 10.1093/ckj/sfad059. eCollection 2023 Sep.
Systemic hypertension is the most common medical comorbidity affecting the adult population globally, with multiple associated outcomes including cerebrovascular diseases, cardiovascular diseases, vascular calcification, chronic kidney disease, metabolic syndrome and mortality. Despite advancements in the therapeutic field approximately one in every five adult patients with hypertension is classified as having treatment-resistant hypertension, indicating the need for studies to provide better understanding of the underlying pathophysiology and the need for more therapeutic targets. Recent pre-clinical studies have demonstrated the role of the innate and adaptive immune system including various cell types and cytokines in the pathophysiology of hypertension. Moreover, pre-clinical studies have indicated the potential beneficial effects of immunosuppressant medications in the control of hypertension. Nevertheless, it is unclear whether such pathophysiological mechanisms and therapeutic alternatives are applicable to human subjects, while this area of research is undoubtedly a rapidly growing field.
系统性高血压是全球影响成年人群的最常见医学合并症，伴有多种相关后果，包括脑血管疾病、心血管疾病、血管钙化、慢性肾病、代谢综合征和死亡。尽管治疗领域取得了进展，但每五名成年高血压患者中约有一名被归类为顽固性高血压，这表明需要开展研究以更好地了解潜在病理生理学，并需要更多治疗靶点。最近的临床前研究已经证明了先天性和适应性免疫系统，包括各种细胞类型和细胞因子在高血压病理生理学中的作用。此外，临床前研究表明免疫抑制药物在控制高血压方面具有潜在的有益作用。然而，尚不清楚这种病理生理机制和治疗选择是否适用于人类受试者，而这一研究领域无疑是一个快速发展的领域。
