Department of Medical Physiology, Texas A&M College of Medicine, Bryan, Texas, USA.
Am J Hypertens. 2022 Oct 3;35(10):842-851. doi: 10.1093/ajh/hpac077.
The contribution of immune cells in the initiation and maintenance of hypertension is undeniable. Several studies have established the association between hypertension, inflammation, and immune cells from the innate and adaptive immune systems. Here, we provide an update to our 2017 American Journal of Hypertension review on the overview of the cellular immune responses involved in hypertension. Further, we discuss the activation of immune cells and their contribution to the pathogenesis of hypertension in different in vivo models. We also highlight existing gaps in the field of hypertension that need attention. The main goal of this review is to provide a knowledge base for translational research to develop therapeutic strategies that can improve cardiovascular health in humans.
免疫细胞在高血压的发生和维持中的作用是不可否认的。有几项研究已经确立了高血压、炎症和先天及适应性免疫系统中的免疫细胞之间的关联。在这里，我们对 2017 年发表在《美国高血压杂志》上的综述进行了更新，概述了参与高血压的细胞免疫反应。此外，我们还讨论了免疫细胞的激活及其在不同体内模型中对高血压发病机制的贡献。我们还强调了高血压领域中需要关注的现有空白。本篇综述的主要目的是为转化研究提供一个知识库，以开发能够改善人类心血管健康的治疗策略。
