用高分辨率的超极化 [1-¹³C]丙酮酸 MRI 研究脑灌注。
Investigating cerebral perfusion with high resolution hyperpolarized [1- C]pyruvate MRI.
机构信息
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA.
出版信息
Magn Reson Med. 2023 Dec;90(6):2233-2241. doi: 10.1002/mrm.29844. Epub 2023 Sep 4.
PURPOSE
To investigate high-resolution hyperpolarized (HP) C pyruvate MRI for measuring cerebral perfusion in the human brain.
METHODS
HP [1- C]pyruvate MRI was acquired in five healthy volunteers with a multi-resolution EPI sequence with 7.5 × 7.5 mm resolution for pyruvate. Perfusion parameters were calculated from pyruvate MRI using block-circulant singular value decomposition and compared to relative cerebral blood flow calculated from arterial spin labeling (ASL). To examine regional perfusion patterns, correlations between pyruvate and ASL perfusion were performed for whole brain, gray matter, and white matter voxels.
RESULTS
High resolution 7.5 × 7.5 mm pyruvate images were used to obtain relative cerebral blood flow (rCBF) values that were significantly positively correlated with ASL rCBF values (r = 0.48, 0.20, 0.28 for whole brain, gray matter, and white matter voxels respectively). Whole brain voxels exhibited the highest correlation between pyruvate and ASL perfusion, and there were distinct regional patterns of relatively high ASL and low pyruvate normalized rCBF found across subjects.
CONCLUSION
Acquiring HP C pyruvate metabolic images at higher resolution allows for finer spatial delineation of brain structures and can be used to obtain cerebral perfusion parameters. Pyruvate perfusion parameters were positively correlated to proton ASL perfusion values, indicating a relationship between the two perfusion measures. This HP C study demonstrated that hyperpolarized pyruvate MRI can assess cerebral metabolism and perfusion within the same study.
目的
研究高分辨率极化（HP） 1- C 丙酮酸 MRI 测量人脑的脑灌注。
方法
使用多分辨率 EPI 序列在五名健康志愿者中获取 HP [1- C]丙酮酸 MRI，该序列具有 7.5×7.5mm 的丙酮酸分辨率。使用块循环奇异值分解从丙酮酸 MRI 计算灌注参数，并与动脉自旋标记（ASL）计算的相对脑血流量进行比较。为了检查区域灌注模式，对整个大脑、灰质和白质体素的丙酮酸和 ASL 灌注进行了相关性分析。
结果
高分辨率 7.5×7.5mm 丙酮酸图像用于获得相对脑血流量（rCBF）值，这些值与 ASL rCBF 值呈显著正相关（整个大脑、灰质和白质体素的 r 分别为 0.48、0.20 和 0.28）。整个大脑体素显示出丙酮酸和 ASL 灌注之间的最高相关性，并且在不同受试者中发现了相对较高的 ASL 和低丙酮酸归一化 rCBF 的明显区域模式。
结论
以更高的分辨率获取 HP 1- C 丙酮酸代谢图像可以更精细地描绘大脑结构，并可用于获得脑灌注参数。丙酮酸灌注参数与质子 ASL 灌注值呈正相关，表明这两种灌注测量之间存在关系。这项 HP 1- C 研究表明，极化丙酮酸 MRI 可以在同一研究中评估脑代谢和灌注。
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