壳聚糖包覆金纳米复合材料对亚历山大萝卜螺的毒理学、肝肾功能、内分泌干扰、氧化应激和免疫组织病理学反应。
Toxicological, hepato-renal, endocrine disruption, oxidative stress and immunohistopathological responses of chitosan capped gold nanocomposite on Biomphalaria alexandrina snails.
机构信息
Medical Malacology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Radiation Chemistry Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.
出版信息
Pestic Biochem Physiol. 2023 Sep;195:105559. doi: 10.1016/j.pestbp.2023.105559. Epub 2023 Jul 27.
The present investigation aimed to synthesize chitosan‑gold nanocomposites (Ch-AuNPs) with gamma radiation, then to evaluate its toxic effect on the freshwater snails Biomphalaia alexandrina. Results showed that Ch-AuNPs is spherical shaped with average size 12 nm. It had a toxic effect against B. alexandrina snails with LC 20.43 mg/l. Exposure of B. alexandrina snails to LC 7.51 or LC 13.63 mg/l of Ch-AuNPs, reduced the survival, reproductive and fecundity rates; total protein and albumin; both testosterone (T) and 17β Estradiol (E) levels; SOD and CAT activities of exposed snails while increased the activities of transaminases (AST & ALT), uric acid, creatinine, TAC and MDA levels compared to the control group. Results were supported by histopathological and immunohistopathological alterations of the digestive and hermaphrodite glands. In conclusion B. alexandrina could be used as a model to screen the negative impact of nanomaterials. Also, Ch-AuNPs could be used as a molluscicidal agent.
本研究旨在通过伽马辐射合成壳聚糖-金纳米复合材料（Ch-AuNPs），然后评估其对淡水蜗牛沼螺的毒性作用。结果表明，Ch-AuNPs 呈球形，平均粒径为 12nm。它对沼螺具有毒性作用，LC20.43mg/L。暴露于 LC7.51 或 LC13.63mg/L 的 Ch-AuNPs 会降低沼螺的存活率、繁殖率和产卵率；总蛋白和白蛋白；雄性激素（T）和 17β 雌二醇（E）水平；SOD 和 CAT 活性，而与对照组相比，暴露组的转氨酶（AST 和 ALT）、尿酸、肌酐、TAC 和 MDA 水平升高。这些结果得到了消化腺和两性腺组织病理学和免疫组织病理学改变的支持。总之，沼螺可作为筛选纳米材料负面影响的模型。此外，Ch-AuNPs 可用作杀软体动物剂。
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