IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia.
Department of Internal Medicine, Hospital del Mar-IMIM, Autonomous University of Barcelona and CIBERFES, Instituto Carlos III, Barcelona, Spain.
Calcif Tissue Int. 2023 Nov;113(5):511-514. doi: 10.1007/s00223-023-01133-9. Epub 2023 Sep 4.
Bone material strength index (BMSi) values are obtained using impact microindentation, which assesses the ability of bone to resist indentation. Differences in BMSi between men and women are unclear, and to date, BMSi sex differences have not been compared for individuals from the same population. Therefore, we compared BMSi values for men and women drawn from the same geographical location in Australia. Participants (n = 220) were from the Geelong Osteoporosis Study. BMSi was measured, following international published guidelines, using an OsteoProbe for participants at recent follow-up phases (women 2022-2023 and men 2016-2022). Women (n = 55) were age matched to men (n = 165) in a 1:3 ratio. A two-sample t test was used to determine the intergroup difference in mean BMSi. Linear regression was also performed, adjusting for weight and height. Median (IQR) ages for men and women were 67.0 (61.7-71.5) and 67.4 (62.0-71.2) years (p = 0.998). Men were heavier (81.0 ± 10.9 vs 71.0 ± 13.9 kg, p < 0.001) and taller (173.9 ± 6.4 vs 161.5 ± 7.5 cm, p < 0.001) than women. Mean (± SD) BMSi for women (75.7 ± 7.4) was lower than for men (82.8 ± 6.8) (p < 0.001). The difference persisted after adjustment for weight and height (mean ± SE: 76.5 ± 1.1 vs 82.5 ± 0.6, p < 0.001). Given the higher fracture risk observed for women, the higher mean BMSi values in men are consistent with cross sectional data suggesting this measure may be useful in fracture prediction.
骨材料强度指数 (BMSi) 值是通过冲击微压痕获得的，该方法评估了骨骼抵抗压痕的能力。男性和女性之间的 BMSi 差异尚不清楚，迄今为止，尚未对来自同一人群的个体进行 BMSi 性别差异比较。因此，我们比较了来自澳大利亚同一地理位置的男性和女性的 BMSi 值。参与者（n=220）来自 Geelong 骨质疏松症研究。根据国际发表的指南，使用 OsteoProbe 测量了参与者在最近随访阶段（女性 2022-2023 年和男性 2016-2022 年）的 BMSi。按照 1:3 的比例，将女性（n=55）与男性（n=165）年龄匹配。使用两样本 t 检验确定组间平均 BMSi 的差异。还进行了线性回归，调整了体重和身高。男性和女性的中位（IQR）年龄分别为 67.0（61.7-71.5）和 67.4（62.0-71.2）岁（p=0.998）。男性比女性更重（81.0±10.9 比 71.0±13.9 kg，p<0.001）和更高（173.9±6.4 比 161.5±7.5 cm，p<0.001）。女性的平均（±SD）BMSi（75.7±7.4）低于男性（82.8±6.8）（p<0.001）。调整体重和身高后，差异仍然存在（平均±SE：76.5±1.1 比 82.5±0.6，p<0.001）。鉴于女性观察到的骨折风险更高，男性较高的平均 BMSi 值与横断面数据一致，表明该指标可能有助于骨折预测。
