Saito M, Terui N, Numao Y, Kumada M
Am J Physiol. 1986 Oct;251(4 Pt 2):H742-7. doi: 10.1152/ajpheart.1986.251.4.H742.
In 21 conscious unrestrained rabbits, arterial pressure was continuously recorded up to 11 wk by an indwelling catheter placed in the thoracic aorta. The average and standard deviation of the 24-h mean arterial pressure (MAP) were calculated and compared before and after sinoaortic denervation, sham operation, or cervical sympathectomy. At the time of sinoaortic denervation, the cervical sympathetic nerve was always disrupted bilaterally to remove possible arterial barosensory afferents contained in it. Subsequent to sinoaortic denervation performed on 12 rabbits, the average 24-h MAP was initially elevated but invariably returned to the predenervation level in 5-36 days (average 14 days). Meanwhile, the standard deviation remained elevated in all but one animal. In five sham-operated or four cervical-sympathectomized animals, neither the average 24-h MAP nor the standard deviation was significantly altered from that of controls. Our results are consistent with the view that the arterial baroreceptor reflex by itself does not play a critical role in determining the long-term level of arterial pressure.
在21只清醒自由活动的兔子中，通过置于胸主动脉的留置导管连续记录动脉血压长达11周。计算并比较了去窦弓神经支配、假手术或颈交感神经切除术前和术后24小时平均动脉压（MAP）的平均值和标准差。在进行去窦弓神经支配时，双侧颈交感神经总是被切断，以去除其中可能包含的动脉压力感受器传入神经。在对12只兔子进行去窦弓神经支配后，24小时平均MAP最初升高，但在5 - 36天内（平均14天）总是恢复到去神经支配前的水平。同时，除一只动物外，所有动物的标准差均保持升高。在五只假手术或四只颈交感神经切除的动物中，24小时平均MAP和标准差与对照组相比均无显著变化。我们的结果与以下观点一致，即动脉压力感受器反射本身在决定动脉血压的长期水平方面并不起关键作用。
