卡托普利与兔去窦主动脉神经支配后的血压维持
Captopril and the maintenance of blood pressure after sinoaortic denervation in the rabbit.
作者信息
Petty M A, Reid J L
出版信息
Br J Pharmacol. 1981 Apr;72(4):645-7. doi: 10.1111/j.1476-5381.1981.tb09144.x.
Abstract
- At a dose of 1 mg/kg intravenously, captopril lowered blood pressure in conscious rabbits, that had undergone denervation of sinoaortic baroreceptors, but had no effect on heart rate. In sham-operated controls, this dose caused only an increase in heart rate. 2. In the same experiments, captopril caused a substantial inhibition of plasma angiotensin converting enzyme (CE) activity of rapid onset and gradual decline over 2 to 3 h. The time course of recovery of blood pressure and plasma CE activity were similar. 3. Saralasin, by intravenous infusion, lowered blood pressure in sinoaortic rabbits but to a smaller extent than captopril. 4. The fall in blood pressure observed after captopril is not dependent on the integrity of baroreceptor afferents.
摘要
- 静脉注射剂量为1毫克/千克时，卡托普利可降低经去窦主动脉压力感受器神经支配的清醒家兔的血压，但对心率无影响。在假手术对照组中，此剂量仅引起心率增加。2. 在相同实验中，卡托普利可显著抑制血浆血管紧张素转换酶（CE）活性，起效迅速，在2至3小时内逐渐下降。血压和血浆CE活性的恢复时间进程相似。3. 静脉输注沙拉新可降低去窦主动脉家兔的血压，但程度小于卡托普利。4. 卡托普利后观察到的血压下降不依赖于压力感受器传入神经的完整性。
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