Blair R W
Am J Physiol. 1986 Oct;251(4 Pt 2):R680-9. doi: 10.1152/ajpregu.1986.251.4.R680.
Neurons in the medullary reticular formation were tested for responses to mechanical stimuli applied to the heart in cats anesthetized with chloralose and paralyzed with pancuronium. In most experiments baroreceptors were denervated. Aortic occlusion excited 15 neurons (19%) and decreased the mean discharge rates of five neurons (6%). Discrete probing of the heart elicited one to three spikes from 18 of 27 neurons tested. Thirteen of these cells had defined cardiac receptive fields; fields were large, often encompassing most of the left ventricle. Of 12 neurons tested for responses during fibrillation, 8 were excited, 2 were inhibited, and 2 were unaffected. Neurons often exhibited different sensitivities to these mechanical stimuli, as well as to ischemia produced during coronary arterial occlusion. Neurons were more likely to respond to stimuli that affected a large mass of myocardium. In addition to cardiac input, 98% of neurons in this study also received input from at least one additional sensory modality, and 39 cells were excited by somatic, auditory, and visual stimuli. Results indicate that medullary reticular neurons are responsive to mechanical events in the heart as well as to myocardial ischemia and respond to other sensory modalities.
在用氯醛糖麻醉并用泮库溴铵麻痹的猫中，测试了延髓网状结构中的神经元对施加于心脏的机械刺激的反应。在大多数实验中，压力感受器被去神经支配。主动脉闭塞兴奋了15个神经元（19%），并降低了5个神经元（6%）的平均放电率。对心脏进行离散探测，在27个测试神经元中的18个中引发了1至3个峰电位。其中13个细胞具有明确的心脏感受野；感受野很大，通常涵盖左心室的大部分。在12个测试了在心房颤动期间反应的神经元中，8个被兴奋，2个被抑制，2个未受影响。神经元对这些机械刺激以及冠状动脉闭塞期间产生的缺血通常表现出不同的敏感性。神经元更有可能对影响大量心肌的刺激做出反应。除了心脏输入外，本研究中98%的神经元还至少从一种其他感觉模态接收输入，并且39个细胞被躯体、听觉和视觉刺激所兴奋。结果表明，延髓网状神经元对心脏中的机械事件以及心肌缺血有反应，并对其他感觉模态有反应。
