Gwon Jun Gyo, Cho Yong-Pil, Han Youngjin, Suh Jungyo, Min Seung-Kee
Division of Vascular Surgery, Department of Surgery, University of Ulsan College of Medicine, Seoul, Korea.
Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Vasc Specialist Int. 2023 Sep 4;39:23. doi: 10.5758/vsi.230056.
Radical nephrectomy with tumor thrombectomy for advanced renal cell carcinoma is an oncologically relevant approach that can achieve long-term survival even in the presence of distant metastases. However, the surgical techniques pose significant challenges. The objective of this clinical review was to present technical recommendations for tumor thrombectomy in the vena cava to facilitate surgical treatment. Transesophageal echocardiography is required to prepare for this procedure. Cardiopulmonary bypass should be considered when the tumor thrombus has invaded the cardiac chamber and clamping is not feasible because of the inability to milk the intracardiac chamber thrombus in the caudal direction. Prior to performing a cavotomy, it is crucial to clamp the contralateral renal vein and infrarenal and suprahepatic inferior vena cava (IVC). If the suprahepatic IVC is separated from the surrounding tissue, it can be gently pulled down toward the patient's leg until the lower margin of the atrium becomes visible. Subsequently, the tumor thrombus should be carefully pulled downward to a position where it can be clamped. Implementing the Pringle maneuver to reduce blood flow from the hepatic veins to the IVC during IVC cavotomy is simpler than clamping the hepatic veins. Sequential clamping is a two-stage method of dividing thrombectomy by clamping the IVC twice, first suprahepatically and then midretrohepatically. This sequential clamping technique helps minimize hypotension status and the Pringle maneuver time compared to single clamping. Additionally, a spiral cavotomy can decrease the degree of primary closure narrowing. The oncological prognoses of patients can be improved by incorporating these technical recommendations.
对于晚期肾细胞癌,行根治性肾切除术并肿瘤血栓切除术是一种具有肿瘤学意义的方法,即使存在远处转移也能实现长期生存。然而,手术技术带来了重大挑战。本临床综述的目的是提出腔静脉肿瘤血栓切除术的技术建议,以促进手术治疗。进行该手术需要经食管超声心动图检查。当肿瘤血栓侵入心腔且由于无法将心腔内血栓向尾端挤出而无法进行钳夹时,应考虑体外循环。在进行腔静脉切开术前,夹闭对侧肾静脉以及肾下和肝上下腔静脉(IVC)至关重要。如果肝上下腔静脉与周围组织分离,可以将其轻轻向下拉向患者腿部,直到心房下缘可见。随后,应小心地将肿瘤血栓向下拉至可进行钳夹的位置。在腔静脉切开术期间实施Pringle手法以减少从肝静脉到腔静脉的血流,比夹闭肝静脉更简单。序贯钳夹是一种分两阶段进行血栓切除术的方法,通过两次夹闭腔静脉,首先在肝上方,然后在肝后中部。与单次夹闭相比,这种序贯钳夹技术有助于将低血压状态和Pringle手法时间降至最低。此外,螺旋形腔静脉切开术可降低一期缝合狭窄的程度。纳入这些技术建议可改善患者的肿瘤学预后。