Li Minhua
Department of Surgical Teaching and Research, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Postgrad Med. 2023 Sep;135(7):701-707. doi: 10.1080/00325481.2023.2255121. Epub 2023 Sep 7.
The current study evaluated the relationship between serum vitamin C and chronic kidney disease.
The database from the National Health and Nutrition Examination Survey (NHANES, 2017-2018) was used to perform a cross-sectional study. Multivariate logistic regression was performed to analyze the relationship between serum vitamin C and chronic kidney disease (CKD), and stratified analysis by sex was performed to assess whether there were sex differences in the association between serum vitamin C and CKD.
Before stratified analysis, multivariate logistic regression showed that serum vitamin C was negatively associated with CKD in all models (All OR > 1, P< 0.05), the risk of CKD decreased by one quantile increase in serum vitamin C (P for trend< 0.001) and low vitamin C status was associated with a higher risk of CKD (All OR > 1, P< 0.05). Stratified analyses by sex showed that the association between serum vitamin C and CKD remained negative in men, but not in women.
There were a negative correlation between serum vitamin C and CKD, low levels of vitamin C were associated with a higher risk of CKD, and these associations were only found in men, but not in women.
本研究评估血清维生素C与慢性肾脏病之间的关系。
使用来自美国国家健康与营养检查调查（NHANES，2017 - 2018年）的数据库进行横断面研究。采用多因素逻辑回归分析血清维生素C与慢性肾脏病（CKD）之间的关系，并按性别进行分层分析，以评估血清维生素C与CKD之间的关联是否存在性别差异。
在分层分析之前，多因素逻辑回归显示，在所有模型中血清维生素C与CKD呈负相关（所有比值比>1，P<0.05），血清维生素C每增加一个分位数，CKD风险降低（趋势P<0.001），低维生素C状态与较高的CKD风险相关（所有比值比>1，P<0.05）。按性别分层分析显示，血清维生素C与CKD之间的关联在男性中仍为负相关，但在女性中并非如此。
血清维生素C与CKD之间存在负相关，低水平维生素C与较高的CKD风险相关，且这些关联仅在男性中发现，在女性中未发现。
