Min Shen Hui, Lei Wang, Jun Chen Jia, Yan Zhang Shao, Guang Yang Xu, Tong Zhang, Yong Zheng Pei, Hui Lu Zhen, Xing Huang
Institute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Expert Opin Investig Drugs. 2023 Jul-Dec;32(8):723-739. doi: 10.1080/13543784.2023.2254683. Epub 2023 Sep 5.
Lung cancer is one of the cancer types with the highest mortality rate, exploring a more effective treatment modality that improves therapeutic efficacy while mitigating side effects is now an urgent requirement. Designing multifunctional nanoparticles can be used to overcome the limitations of drugs and conventional drug delivery systems. Nanotechnology has been widely researched, and through different needs, suitable nanocarriers can be selected to load anti-cancer drugs to improve the therapeutic effect. It is foreseeable that with the rapid development of nanotechnology, more and more lung cancer patients will benefit from nanotechnology. This paper reviews the merits of various multifunctional nanoparticles in the treatment of lung cancer to provide novel ideas for lung cancer treatment.
This review focuses on summarizing various nanoparticles for targeted lung cancer therapy and their advantages and disadvantages, using nanoparticles loaded with anti-cancer drugs, delivered to lung cancer sites, enhancing drug half-life, improving anti-cancer drug efficacy and reducing side effects.
The delivery mode of nanoparticles with superior pharmacokinetic properties in the in vivo circulation enhances the half-life of the drug, and provides tissue-targeted selectivity and the ability to overcome biological barriers, bringing a revolution in the field of oncology.
肺癌是死亡率最高的癌症类型之一，探索一种在提高治疗效果的同时减轻副作用的更有效治疗方式是当务之急。设计多功能纳米颗粒可用于克服药物及传统给药系统的局限性。纳米技术已得到广泛研究，通过不同需求可选择合适的纳米载体来负载抗癌药物以提高治疗效果。可以预见，随着纳米技术的快速发展，越来越多的肺癌患者将受益于纳米技术。本文综述了各种多功能纳米颗粒在肺癌治疗中的优点，为肺癌治疗提供新思路。
本综述着重总结用于肺癌靶向治疗的各种纳米颗粒及其优缺点，利用负载抗癌药物的纳米颗粒递送至肺癌部位，延长药物半衰期，提高抗癌药物疗效并减少副作用。
具有优异药代动力学性质的纳米颗粒在体内循环中的递送方式可延长药物半衰期，并提供组织靶向选择性及克服生物屏障的能力，给肿瘤学领域带来一场变革。
