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改变策略:刺激响应性聚合物系统在生物医学科学中的前景。

Switching it Up: The Promise of Stimuli-Responsive Polymer Systems in Biomedical Science.

作者信息

Shymborska Yana, Budkowski Andrzej, Raczkowska Joanna, Donchak Volodymyr, Melnyk Yuriy, Vasiichuk Viktor, Stetsyshyn Yurij

机构信息

Lviv Polytechnic National University, St. George's Square 2, 79013, Lviv, Ukraine.

Jagiellonian University, Faculty of Physics, Astronomy and Applied Computer Science, Smoluchowski Institute of Physics, Łojasiewicza 11, 30-348, Kraków, Poland.

出版信息

Chem Rec. 2024 Feb;24(2):e202300217. doi: 10.1002/tcr.202300217. Epub 2023 Sep 5.

Abstract

Responsive polymer systems have the ability to change properties or behavior in response to external stimuli. The properties of responsive polymer systems can be fine-tuned by adjusting the stimuli, enabling tailored responses for specific applications. These systems have applications in drug delivery, biosensors, tissue engineering, and more, as their ability to adapt and respond to dynamic environments leads to improved performance. However, challenges such as synthesis complexity, sensitivity limitations, and manufacturing issues need to be addressed for successful implementation. In our review, we provide a comprehensive summary on stimuli-responsive polymer systems, delving into the intricacies of their mechanisms and actions. Future developments should focus on precision medicine, multifunctionality, reversibility, bioinspired designs, and integration with advanced technologies, driving the dynamic growth of sensitive polymer systems in biomedical applications.

摘要

响应性聚合物系统具有响应外部刺激而改变性质或行为的能力。通过调整刺激因素,可以对响应性聚合物系统的性质进行微调,从而实现针对特定应用的定制响应。这些系统在药物递送、生物传感器、组织工程等领域都有应用,因为它们适应和响应动态环境的能力可带来性能的提升。然而,要成功实施,还需要解决诸如合成复杂性、灵敏度限制和制造问题等挑战。在我们的综述中,我们对刺激响应性聚合物系统进行了全面总结,深入探讨了其机制和作用的复杂性。未来的发展应聚焦于精准医学、多功能性、可逆性、仿生设计以及与先进技术的整合,推动敏感聚合物系统在生物医学应用中的动态发展。

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