Saadh Mohamed J, Makasana Jayanti, Ballal Suhas, R Roopashree, Verma Lokesh, Pathak Piyus Kumar, Saud Haider Radhi, Saini Suman, Bhakuni Pushpa Negi, Sead Fadhil Faez
Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan.
Department of Chemistry, Faculty of Science, Marwadi University Research Center, Marwadi University, Rajkot, Gujarat, 360003, India.
Med Oncol. 2025 May 12;42(6):208. doi: 10.1007/s12032-025-02768-4.
Chitosan-based nanocomposites have emerged as promising platforms in hyperthermia-mediated cancer therapy due to their unique physicochemical properties, biocompatibility, and functional versatility. This review highlights recent advances in the design and application of chitosan-functionalized nanoparticles (NPs), focusing on their role in enhancing targeted hyperthermic treatment. The integration of chitosan with various nanomaterials-including magnetic nanoparticles, carbon-based structures such as graphene and carbon nanotubes, and gold nanoparticles-offers distinct advantages in thermal conversion efficiency, tumor specificity, and drug delivery potential. Magnetic nanoparticles allow precise thermal ablation of cancer cells under an external magnetic field, while carbon-based materials provide superior thermal conductivity for efficient heat generation. Gold nanoparticles, when conjugated with chitosan, improve biocompatibility and enable surface modification for targeted therapy. Despite promising preclinical outcomes, challenges remain in terms of toxicity, long-term stability, regulatory approval, and scalable synthesis. This review critically examines these aspects and outlines future directions for optimizing chitosan-based nanocomposites toward clinical translation and commercial viability in cancer hyperthermia therapy.
基于壳聚糖的纳米复合材料因其独特的物理化学性质、生物相容性和功能多样性，已成为热疗介导的癌症治疗中有前景的平台。本综述重点介绍了壳聚糖功能化纳米粒子（NPs）设计与应用的最新进展，着重阐述其在增强靶向热疗中的作用。壳聚糖与各种纳米材料（包括磁性纳米粒子、石墨烯和碳纳米管等碳基结构以及金纳米粒子）的结合，在热转换效率、肿瘤特异性和药物递送潜力方面具有明显优势。磁性纳米粒子可在外部磁场下对癌细胞进行精确热消融，而碳基材料具有优异的热导率，可有效产热。与壳聚糖结合的金纳米粒子可提高生物相容性，并实现用于靶向治疗的表面修饰。尽管临床前结果很有前景，但在毒性、长期稳定性、监管批准和可扩展合成方面仍存在挑战。本综述批判性地审视了这些方面，并概述了优化基于壳聚糖的纳米复合材料以实现癌症热疗临床转化和商业可行性的未来方向。
