Laboratory of Microbiota and Immunomodulation - Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil.
Department of Clinical Analysis, School of Pharmacy, Universidade Federal de Ouro Preto - UFOP, Ouro Preto, Brazil.
Gut Microbes. 2023 Dec;15(2):2249146. doi: 10.1080/19490976.2023.2249146.
Long-term sequelae of coronavirus disease (COVID)-19 are frequent and of major concern. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects the host gut microbiota, which is linked to disease severity in patients with COVID-19. Here, we report that the gut microbiota of post-COVID subjects had a remarkable predominance of strains with an antibiotic-resistant phenotype compared to healthy controls. Additionally, short-chain fatty acid (SCFA) levels were reduced in feces. Fecal transplantation from post-COVID subjects to germ-free mice led to lung inflammation and worse outcomes during pulmonary infection by multidrug-resistant . transplanted mice also exhibited poor cognitive performance. Overall, we show prolonged impacts of SARS-CoV-2 infection on the gut microbiota that persist after subjects have cleared the virus. Together, these data demonstrate that the gut microbiota can directly contribute to post-COVID sequelae, suggesting that it may be a potential therapeutic target.
新冠病毒疾病（COVID-19）的长期后遗症较为常见且令人担忧。严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染会影响宿主肠道微生物群，这与 COVID-19 患者的疾病严重程度有关。在这里，我们报告称，与健康对照组相比，新冠后个体的肠道微生物群中具有抗生素耐药表型的菌株显著占优势。此外，粪便中的短链脂肪酸（SCFA）水平降低。将新冠后个体的粪便移植到无菌小鼠中，导致肺部感染多重耐药菌时发生肺部炎症和更差的结果。移植的小鼠也表现出较差的认知能力。总的来说，我们发现 SARS-CoV-2 感染对肠道微生物群的长期影响在个体清除病毒后仍然存在。总之，这些数据表明，肠道微生物群可能直接导致新冠后遗症，提示其可能是一个潜在的治疗靶点。
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