Monje Michelle, Iwasaki Akiko
Department of Neurology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, USA.
Department of Immunobiology, Yale University, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University, USA.
Neuron. 2022 Nov 2;110(21):3484-3496. doi: 10.1016/j.neuron.2022.10.006. Epub 2022 Oct 7.
Persistent neurological and neuropsychiatric symptoms affect a substantial fraction of people after COVID-19 and represent a major component of the post-acute COVID-19 syndrome, also known as long COVID. Here, we review what is understood about the pathobiology of post-acute COVID-19 impact on the CNS and discuss possible neurobiological underpinnings of the cognitive symptoms affecting COVID-19 survivors. We propose the chief mechanisms that may contribute to this emerging neurological health crisis.
持续性神经和神经精神症状在新冠病毒病（COVID-19）康复后影响相当一部分人，是急性后COVID-19综合征（也称为长期COVID）的主要组成部分。在此，我们回顾了目前对急性后COVID-19影响中枢神经系统的病理生物学的理解，并讨论了影响COVID-19幸存者的认知症状可能的神经生物学基础。我们提出了可能导致这一新兴神经健康危机的主要机制。
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