Azuz Samuel, Poulsen Jakob Lykke, Vinter-Jensen Lars, Olesen Anne Estrup
Department of Clinical Pharmacology, Aalborg University Hospital, Aalborg, Denmark.
Center for Nutrition and Bowel Disease, Department of Gastroenterology, Aalborg University Hospital, Aalborg, Denmark.
Expert Opin Drug Metab Toxicol. 2023 Sep;19(9):577-600. doi: 10.1080/17425255.2023.2256216. Epub 2023 Sep 8.
Drug absorption is often altered and typically diminished in patients with short bowel syndrome (SBS). It is important to understand the patient's gastrointestinal anatomy, the absorptive capacity of the remaining bowel, and the physicochemical and pharmacokinetic properties of the drug to optimize oral pharmacotherapy.
The primary focus was to provide an updated understanding of the absorption of various drugs in patients with short bowel syndrome. Forty-seven studies covering 13 different drug classes were included in the review and study details, patient characteristics, drug characteristics and pharmacokinetic findings were summarized for each drug class.
Improving and simplifying drug treatment in patients with SBS have high priority, but the patients are multi diseased so knowledge regarding absorption of drugs as e.g. antithrombotic agents, immunosuppressants is urgently needed. Therefore, it is crucial to advance our understanding of the fundamental factors involved in drug absorption, spanning from drug design to pathophysiology. With the growing knowledge in drug design and gastrointestinal pathophysiology, we anticipate the development of computer models that can accurately predict optimal absorption in the future.
短肠综合征（SBS）患者的药物吸收通常会发生改变，且往往会降低。了解患者的胃肠道解剖结构、剩余肠道的吸收能力以及药物的物理化学和药代动力学特性对于优化口服药物治疗非常重要。
主要重点是更新对短肠综合征患者各种药物吸收情况的理解。该综述纳入了47项涉及13种不同药物类别的研究，并针对每种药物类别总结了研究细节、患者特征、药物特性和药代动力学研究结果。
改善和简化短肠综合征患者的药物治疗具有高度优先性，但这些患者患有多种疾病，因此迫切需要有关抗血栓药物、免疫抑制剂等药物吸收的知识。因此，加深我们对从药物设计到病理生理学等药物吸收所涉及的基本因素的理解至关重要。随着药物设计和胃肠道病理生理学知识的不断增加，我们预计未来能够准确预测最佳吸收情况的计算机模型将会得到发展。
