Gentry J F
Am J Surg Pathol. 1986 Oct;10(10):718-27. doi: 10.1097/00000478-198610000-00008.
Touch imprint cytology is a simple, rapid, reliable, and highly sensitive procedure when used for detecting lymph node metastases in men with clinically localized prostatic adenocarcinoma who are undergoing staging pelvic lymphadenectomy. Thirty-five men admitted for this procedure had frozen sections performed on the lymph nodes removed at surgery. Of these 35 patients, 19 had touch imprints made of their lymph nodes. In five patients classified as having Stage D disease, positive frozen section correlated with permanent section. In two of these cases, touch imprint cytology was performed and was positive for malignant cells. In seven patients classified as having Stage D disease, frozen sections were negative. Permanent sections were positive for metastatic tumor in five of these patients. In four of these cases, touch imprint cytology was performed. In two cases, cytology and permanent sections were positive and, in two cases, cytology alone was positive. Factors that contributed to the false negative rate for frozen section were: the presence of micrometastases, fatty lymph nodes that were difficult to process, and sampling errors on the part of the pathologist. Touch imprint cytology overcame the deficits of frozen section and proved useful in detecting metastatic disease in lymph nodes.
对于接受分期盆腔淋巴结清扫术的临床局限性前列腺腺癌男性患者，触摸印片细胞学检查是一种用于检测淋巴结转移的简单、快速、可靠且高度敏感的方法。35名因该手术入院的男性患者在手术切除的淋巴结上进行了冰冻切片检查。在这35名患者中，19名患者对其淋巴结进行了触摸印片。在5名被归类为D期疾病的患者中，冰冻切片阳性与永久切片结果相关。在其中2例病例中，进行了触摸印片细胞学检查，结果显示恶性细胞呈阳性。在7名被归类为D期疾病的患者中，冰冻切片为阴性。在其中5名患者中，永久切片显示有转移性肿瘤阳性。在这4例病例中，进行了触摸印片细胞学检查。在2例病例中，细胞学检查和永久切片均为阳性，在另外2例病例中，仅细胞学检查呈阳性。导致冰冻切片假阴性率的因素包括：微转移灶的存在、难以处理的脂肪性淋巴结以及病理学家的采样误差。触摸印片细胞学检查克服了冰冻切片的不足，在检测淋巴结转移性疾病方面被证明是有用的。
