Singletary S E, Byers R M, Shallenberger R, McBride C M, Guinee V F
Am J Surg. 1986 Oct;152(4):371-5. doi: 10.1016/0002-9610(86)90307-7.
A retrospective analysis with a minimum 10 year follow-up was performed on 287 patients who underwent radical or modified neck dissections with histologically involved regional nodal metastases from cutaneous malignant melanoma. The cumulative 5 year and 10 year survival rates calculated from the time of node dissection were 33 percent and 28 percent, respectively. Age and sex of the patient, site of known primary tumor, clinical stage at presentation, and time interval from the treatment of the primary tumor to node dissection did not independently affect survival. However, an unknown site of primary disease, the presence of only one histologically involved node, and the absence of extranodal tumor invasion at the time of node dissection were statistically significant individual prognostic factors for an improved survival rate.
对287例因皮肤恶性黑色素瘤出现组织学证实的区域淋巴结转移而接受根治性或改良颈部清扫术的患者进行了一项至少随访10年的回顾性分析。从淋巴结清扫时间开始计算的5年和10年累积生存率分别为33%和28%。患者的年龄和性别、已知原发肿瘤的部位、就诊时的临床分期以及从原发肿瘤治疗到淋巴结清扫的时间间隔均未独立影响生存率。然而，原发疾病部位不明、仅存在一个组织学受累淋巴结以及淋巴结清扫时无结外肿瘤侵犯是生存率提高的具有统计学意义的个体预后因素。
