Schantz S P, Campbell B H, Guillamondegui O M
Am J Surg. 1986 Oct;152(4):467-74. doi: 10.1016/0002-9610(86)90326-0.
An evaluation of natural killer cell activity was performed in 42 patients with pharyngeal carcinoma. Compared with age- and sex-matched control subjects, the cancer patients expressed significantly lower cytotoxicity against K562 target cells (68 +/- 8 lytic units versus 99 +/- 8 lytic units, p less than 0.01), with 52 percent of the patients expressing deficient activity (below 1 standard deviation of the mean activity of the control population). The probability of deficient activity was greater in these patients than observed in patients with cancer of other head and neck sites. Although natural killer cell activity was lower in patients who drank alcohol or had nodal metastases, no single clinical factor was predictive of deficient cytotoxic response. Prospective longitudinal evaluation (mean = 12 months) of these pharyngeal cancer patients demonstrated that deficient natural killer cell activity measured before treatment identified a population with a significantly increased risk for the development of distant metastases. Distant metastases developed in 7 of 18 patients (39 percent) with deficient natural killer cell activity. In contrast, none of the 16 patients with normal natural killer cell function had evidence of distant disease at last follow-up (p less than 0.01). Deficient natural killer cell activity exists in patients with pharyngeal cancer and is an independent marker for the subsequent development of distant metastases.
对42例咽癌患者进行了自然杀伤细胞活性评估。与年龄和性别匹配的对照受试者相比，癌症患者对K562靶细胞的细胞毒性显著降低（68±8个裂解单位对99±8个裂解单位，p<0.01），52%的患者表现出活性不足（低于对照人群平均活性的1个标准差）。这些患者活性不足的概率高于其他头颈部位癌症患者。虽然饮酒或有淋巴结转移的患者自然杀伤细胞活性较低，但没有单一临床因素可预测细胞毒性反应不足。对这些咽癌患者进行的前瞻性纵向评估（平均12个月）表明，治疗前测得的自然杀伤细胞活性不足可识别出远处转移发生风险显著增加的人群。18例自然杀伤细胞活性不足的患者中有7例（39%）发生了远处转移。相比之下，16例自然杀伤细胞功能正常的患者在最后一次随访时均无远处疾病证据（p<0.01）。咽癌患者存在自然杀伤细胞活性不足，且是远处转移后续发生的独立标志物。
