Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Small. 2024 Jan;20(3):e2306208. doi: 10.1002/smll.202306208. Epub 2023 Sep 5.
Nanotechnology-based strategy has recently drawn extensive attention for the therapy of malignant tumors due to its distinct strengths in cancer diagnosis and treatment. However, the limited intratumoral permeability of nanoparticles is a major hurdle to achieving the desired effect of cancer treatment. Due to their superior cargo towing and reliable penetrating property, micro-/nanomotors (MNMs) are considered as one of the most potential candidates for the coming generation of drug delivery platforms. Here, near-infrared (NIR)-actuated biomimetic nanomotors (4T1-JPGSs-IND) are fabricated successfully and we demonstrate that 4T1-JPGSs-IND selectively accumulate in homologous tumor regions due to the effective homing ability. Upon laser irradiation, hyperthermia generated by 4T1-JPGSs-IND leads to self-thermophoretic motion and photothermal therapy (PTT) to ablate tumors with a deep depth, thereby improving the photothermal therapeutic effect for cancer management. The developed nanomotor system with multifunctionalities exhibits promising potential in biomedical applications to fight against various diseases.
基于纳米技术的策略由于在癌症诊断和治疗方面具有明显的优势，最近引起了广泛关注。然而，纳米颗粒在肿瘤内的有限通透性是实现癌症治疗预期效果的主要障碍。由于其优越的货物牵引和可靠的穿透特性，微/纳米马达（MNMs）被认为是下一代药物输送平台最有潜力的候选者之一。在这里，成功制备了近红外（NIR）驱动的仿生纳米马达（4T1-JPGSs-IND），并证明由于有效的归巢能力，4T1-JPGSs-IND 选择性地积聚在同源肿瘤区域。激光照射后，4T1-JPGSs-IND 产生的热疗会导致自热泳运动和光热治疗（PTT），以消融深度较大的肿瘤，从而提高癌症治疗的光热治疗效果。该多功能纳米马达系统在对抗各种疾病的生物医学应用中具有广阔的应用前景。
