苄基吡啶醚的均偶联：可见光介导的脱氧反应
Homocoupling of benzyl pyridyl ethers visible light-mediated deoxygenation.
作者信息
Chen Jingtian, Wang Fan, Li Xiang, Wang Lei, Yu Wei, Sun Keju, Yang Jingyue
机构信息
State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Nano-biotechnology, Hebei Key Laboratory of Applied Chemistry, Yanshan University, Qinhuangdao, 066004, P. R. China.
Qinhuangdao Customs Technical Center, Qinhuangdao, 066004, P. R. China.
出版信息
Chem Commun (Camb). 2023 Sep 21;59(76):11409-11412. doi: 10.1039/d3cc03002d.
The photocatalytic coupling of ethers is uncommon because of the challenges in breaking C-O bonds and low selectivity. Herein, we report a visible light-mediated deoxygenation homocoupling of benzyl pyridyl ethers their pyridium salts. This approach enables C(sp)-O bond homolysis under mild conditions. Mechanistic experiments support the radical nature of the reaction. This method is highly compatible with electron-withdrawing groups and has potential applications for drug precursor synthesis.
由于断裂C-O键存在挑战且选择性较低，醚的光催化偶联并不常见。在此，我们报道了苄基吡啶醚与其吡啶盐的可见光介导脱氧均偶联反应。该方法能够在温和条件下实现C(sp)-O键的均裂。机理实验支持了该反应的自由基性质。此方法与吸电子基团具有高度兼容性，在药物前体合成方面具有潜在应用。
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