McMillan B C, Hanson R P
Am J Vet Res. 1986 Sep;47(9):1905-9.
Many Newcastle disease virus strains are composed of several biotypes which coexist in the wild and in laboratory cultures. We have studied some of the phenotypic and genotypic properties of 6 virus clones from the coexisting biotypes of the Hickman strain of Newcastle disease virus. These clones were readily distinguishable from the parent virus strain and from each other by their RNA fingerprints. Fingerprints of the most virulent clones (Hi/LC, Hi/MC, and Hi/LR) contained 61% to 77% of the oligoribonucleotides present in the fingerprint of the Hickman parent strain. None of the clones killed chickens as rapidly as did the parent strain, although some clones killed embryonating eggs as rapidly as did the parent strain.
许多新城疫病毒株由几种生物型组成，它们在野外和实验室培养物中共同存在。我们研究了来自新城疫病毒希克曼株共存生物型的6个病毒克隆的一些表型和基因型特性。通过RNA指纹图谱，这些克隆很容易与亲本病毒株以及彼此区分开来。最具毒力的克隆（Hi/LC、Hi/MC和Hi/LR）的指纹图谱包含了希克曼亲本株指纹图谱中61%至77%的寡核糖核苷酸。尽管一些克隆杀死胚胎蛋的速度与亲本株一样快，但没有一个克隆杀死鸡的速度与亲本株一样快。
