Neurology, Federal University of the Parnaíba Delta, Parnaíba, Brazil.
Headache, Headache Center of Rio, Rio de Janeiro, Brazil.
Headache. 2023 Sep;63(8):1070-1075. doi: 10.1111/head.14608. Epub 2023 Sep 6.
Children and adolescents may experience pain in the lower limbs, predominantly at the end of the day or during the night, without any relation to organic disease. These pains are often called "growing pains" (GP) by pediatricians and orthopedists. They are commonly attributed to rapid growth.
The aim of this study was to review and characterize GP in children and adolescents as a precursor/comorbidity with migraine.
The study was of a cross-sectional, prospective, longitudinal cohort, with group comparison. A sample of 100 children/adolescents born to mothers with migraine seen at a headache clinic was recruited in a random order chosen by lot, maintaining the ratio of 1:1 for the group with GP and the controls. Both groups were followed for a period of 5 years.
After 5 years of follow-up, 78 patients completed the study, of which 42 were from the GP group and 36 were from the control group. Headache fulfilling the International Classification of Headache Disorders, 3rd edition diagnostic criteria for migraine without aura or probable migraine occurred in 32/42 (76%) of patients with GP and in 8/36 (22%) of controls (p < 0.001). In the sample that initially had "growing pains," these pains persisted in 6/42 (14%) and appeared in 14/36 (39%) of those who were previously asymptomatic (p = 0.026).
Pain in the lower limbs of children and adolescents, commonly referred to as GP by pediatricians and orthopedists, may reflect a precursor or comorbidity with migraine.
儿童和青少年可能会经历下肢疼痛，主要发生在一天结束时或夜间，与器质性疾病无关。这些疼痛通常被儿科医生和矫形外科医生称为“生长痛”（GP）。它们通常归因于快速生长。
本研究旨在回顾和描述儿童和青少年的 GP 作为偏头痛的前驱症状/共病。
该研究为横断面、前瞻性、纵向队列研究，进行组间比较。通过抽签随机选择偏头痛母亲就诊头痛诊所的 100 名儿童/青少年作为样本，按照 1:1 的比例将有 GP 组和对照组纳入研究。两组均随访 5 年。
随访 5 年后，78 例患者完成了研究，其中 42 例来自 GP 组，36 例来自对照组。符合国际头痛疾病分类第 3 版无先兆偏头痛或可能偏头痛诊断标准的头痛在 42 例 GP 患者中有 32 例（76%），36 例对照组中有 8 例（22%）（p<0.001）。在最初有“生长痛”的样本中，这些疼痛在 42 例中的 6 例（14%）中持续存在，在 36 例中原本无症状的 14 例（39%）中出现（p=0.026）。
儿科医生和矫形外科医生常称为 GP 的儿童和青少年下肢疼痛可能反映了偏头痛的前驱症状或共病。
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