Eder J, Simon M S, Glocker C, Musil R
Klinik für Psychiatrie und Psychotherapie, Klinikum der Universität (LMU) München, Nußbaumstraße 7, 80336, München, Deutschland.
Oberberg Fachklinik Bad Tölz, Bad Tölz, Deutschland.
Nervenarzt. 2023 Sep;94(9):859-869. doi: 10.1007/s00115-023-01534-z. Epub 2023 Sep 6.
Psychotropic drug-induced weight gain (PIWG) is a well-known and frequent side effect which is relevant for the prognosis of patients. Individual medications have varying risks for the occurrence of PIWG, and at the same time there are individual risk factors on the part of patients, such as age, gender, metabolic and genetic factors. As the metabolic changes in the context of PIWG result in increased mortality in the long term, it is important to prevent PIWG by appropriate prevention and to intervene in a targeted manner if PIWG has already occurred. Appropriate monitoring is therefore essential. This article provides an overview of underlying mechanisms, risk constellations and possible countermeasures.
精神药物所致体重增加（PIWG）是一种众所周知且常见的副作用，与患者的预后相关。不同的精神药物导致PIWG的风险各异，同时患者自身也存在个体风险因素，如年龄、性别、代谢和遗传因素。由于PIWG背景下的代谢变化会导致长期死亡率增加，因此通过适当的预防措施来预防PIWG，并在PIWG已经发生时进行有针对性的干预非常重要。因此，适当的监测至关重要。本文概述了其潜在机制、风险因素组合及可能的应对措施。
