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大气短期空气污染暴露与结膜炎日门诊就诊量关联的最新研究:中国杭州的一项时间序列研究。

An update on the association between ambient short-term air pollution exposure and daily outpatient visits for conjunctivitis: a time-series study in Hangzhou, China.

机构信息

School of Public Health, Zhejiang Academy of Medical Sciences, Hangzhou Medical College, No.182, Tianmushan Road Zhejiang Province, Hangzhou, 310013, China.

Affiliated Hospital of Hangzhou Normal University, Zhejiang Province, Hangzhou, China.

出版信息

Environ Sci Pollut Res Int. 2023 Oct;30(46):102790-102802. doi: 10.1007/s11356-023-29647-7. Epub 2023 Sep 6.

Abstract

Air pollution is a major public health problem that can lead to conjunctivitis. This study aimed to explore the associations between air pollutants and outpatient visits for conjunctivitis in Hangzhou, China. This study collected data on 50,772 patients with conjunctivitis and the concentrations of six air pollutants from February 1, 2014, to August 31, 2018. A time series analysis using a generalized additive model (GAM) was conducted. We found that the risk of conjunctivitis was related to the air pollutants PM2.5, PM10, SO, NO, and O, which had concentration hysteresis effects. The risk of conjunctivitis increased by 1.009 (95% confidence interval (CI): 1.003, 1.014), 1.011 (95% CI: 1.008, 1.015), 1.238 (95% CI: 1.186, 1.292), 1.028 (95% CI: 1.019, 1.038), and 1.013 (95% CI: 1.008, 1.017) for every 10 µg/m increase in PM2.5, PM10, SO, NO, and O concentrations, respectively. The lag effects of SO and NO were stronger than those of particulate matter. Females exposed to PM10, PM2.5, SO, and O had a higher risk of conjunctivitis than males, while males exposed to NO had a nearly identical risk of conjunctivitis as females. People aged 19-59 were more likely to suffer from conjunctivitis. The risk of conjunctivitis caused by PM10, SO, and O was highest in the transitional season, while the risk caused by NO was highest in the winter season. In conclusion, females and middle-aged adults were at higher risk of conjunctivitis. People were more susceptible to conjunctivitis during the transitional season. These findings highlight the importance of atmospheric pollution governance and reference for public health measures.

摘要

空气污染是一个主要的公共卫生问题,可导致结膜炎。本研究旨在探索中国杭州市空气污染物与结膜炎门诊就诊的关系。本研究收集了 2014 年 2 月 1 日至 2018 年 8 月 31 日期间 50772 例结膜炎患者和 6 种空气污染物浓度的数据。采用广义相加模型(GAM)进行时间序列分析。我们发现,结膜炎的发病风险与 PM2.5、PM10、SO、NO 和 O 等空气污染物有关,具有浓度滞后效应。结膜炎的发病风险分别增加了 1.009(95%置信区间(CI):1.003,1.014)、1.011(95% CI:1.008,1.015)、1.238(95% CI:1.186,1.292)、1.028(95% CI:1.019,1.038)和 1.013(95% CI:1.008,1.017),每增加 10μg/m3 PM2.5、PM10、SO、NO 和 O 浓度。SO 和 NO 的滞后效应强于颗粒物。暴露于 PM10、PM2.5、SO 和 O 的女性患结膜炎的风险高于男性,而暴露于 NO 的男性患结膜炎的风险与女性几乎相同。19-59 岁的人更容易患结膜炎。PM10、SO 和 O 引起的结膜炎风险在过渡季节最高,而 NO 引起的结膜炎风险在冬季最高。总之,女性和中年成年人患结膜炎的风险更高。过渡季节人们更容易患结膜炎。这些发现强调了大气污染治理的重要性,为公共卫生措施提供了参考。

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