Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Transl Vis Sci Technol. 2023 Sep 1;12(9):3. doi: 10.1167/tvst.12.9.3.
We explored the retinal microvascular changes in carotid artery stenosis (CAS) and their relationship with carotid plaque morphology.
All participants were diagnosed with carotid artery stenosis by a neurologist. Participants underwent digital subtraction angiography (DSA) and optical coherence tomography angiography (OCTA) imaging. The degree and length of carotid plaque were obtained from the DSA tool. OCTA tool measured the densities in the superficial vascular complex (SVC) and deep vascular complex (DVC).
One hundred seventeen patients with CAS patients were included in our data analysis. Eyes with ipsilateral stenosis had reduced retinal microvascular densities when compared to contralateral eyes in patients with CAS (P = 0.016 for SVC, and P = 0.004 for DVC). Microvascular densities correlated with the length of carotid plaque (P = 0.015 for SVC, and P = 0.022 for DVC) in our CAS cohort, although they did not correlate with the degree of carotid plaque (P = 0.264 for SVC, and P = 0.298 for DVC). However, when stratified into moderate and severe subgroups, the degree of carotid plaque correlated with microvascular densities in patients with severe stenosis (P = 0.045 for SVC, and P = 0.038 for DVC).
Our study suggests that OCTA can noninvasively detect retinal microvascular changes in patients with CAS and that these changes correlated with the length of the stenosis, but future studies are required to confirm these findings.
Noninvasive and rapid acquisition of the OCTA image might have the potential to be used as a screening tool to detect microvascular changes in carotid artery stenosis.
本研究旨在探讨颈动脉狭窄（CAS）患者视网膜微血管变化及其与颈动脉斑块形态的关系。
所有患者均由神经科医生诊断为颈动脉狭窄。患者行数字减影血管造影（DSA）和光相干断层扫描血管造影（OCTA）检查。DSA 工具获取颈动脉斑块的程度和长度，OCTA 工具测量浅层血管丛（SVC）和深层血管丛（DVC）的密度。
本研究共纳入 117 例 CAS 患者。与对侧眼相比，CAS 患者患侧眼的视网膜微血管密度降低（SVC：P = 0.016，DVC：P = 0.004）。在我们的 CAS 队列中，微血管密度与颈动脉斑块的长度相关（SVC：P = 0.015，DVC：P = 0.022），但与颈动脉斑块的程度无关（SVC：P = 0.264，DVC：P = 0.298）。然而，当分为中度和重度亚组时，严重狭窄患者的颈动脉斑块程度与微血管密度相关（SVC：P = 0.045，DVC：P = 0.038）。
本研究表明，OCTA 可无创检测 CAS 患者的视网膜微血管变化，且这些变化与狭窄程度相关，但需要进一步研究来证实这些发现。
本文是机器翻译，仅供参考。
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