Department of Pediatrics, Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO.
Diabetes Care. 2023 Dec 1;46(12):2155-2161. doi: 10.2337/dc23-0350.
To assess anxiety and risk perception among parents whose children screened positive for islet autoantibodies, indicating elevated risk for type 1 diabetes (T1D).
The Autoimmunity Screening for Kids (ASK) study identified 319 children age 1 to 17 years at risk for T1D via screening for islet autoantibodies; 280 children with confirmed islet autoantibodies and their caregivers enrolled in a follow-up education and monitoring program to prevent diabetic ketoacidosis at diagnosis. Parents completed questionnaires at each monitoring visit, including a 6-item version of the State Anxiety Inventory (SAI), to assess anxiety about their child developing T1D, and a single question to assess risk perception.
At the first ASK follow-up monitoring visit, mean parental anxiety was elevated above the clinical cutoff of 40 (SAI 46.1 ± 11.2). At the second follow-up monitoring visit (i.e., visit 2), mean anxiety remained elevated but started to trend down. Approximately half (48.9%) of parents reported their child was at increased risk for T1D at the initial follow-up monitoring visit (visit 1). Parents of children with more than one islet autoantibody and a first-degree relative with T1D were more likely to report their child was at increased risk.
Most parents of autoantibody-positive children have high anxiety about their child developing T1D. Information about the risk of developing T1D is difficult to convey, as evidenced by the wide range of risk perception reported in this sample.
评估自身抗体阳性儿童的父母的焦虑和风险感知，这些儿童的自身抗体阳性提示其患 1 型糖尿病（T1D）的风险增加。
Autoimmunity Screening for Kids（ASK）研究通过对胰岛自身抗体进行筛查，发现了 319 名年龄在 1 至 17 岁之间有患 T1D 风险的儿童；280 名自身抗体阳性且其照顾者的儿童参加了后续的教育和监测计划，以预防诊断时发生糖尿病酮症酸中毒。父母在每次监测就诊时完成了问卷，包括状态焦虑量表（SAI）的 6 项版本，以评估其子女患 T1D 的焦虑程度，以及评估风险感知的单一问题。
在 ASK 的首次随访监测就诊时，父母的平均焦虑水平高于临床临界值 40（SAI 46.1 ± 11.2）。在第二次随访监测就诊（即就诊 2）时，平均焦虑仍处于高位，但开始呈下降趋势。大约一半（48.9%）的父母在首次随访监测就诊（就诊 1）时报告其子女患 T1D 的风险增加。自身抗体阳性且有 T1D 一级亲属的儿童的父母更有可能报告其子女的风险增加。
大多数自身抗体阳性儿童的父母对其子女患 T1D 的焦虑程度较高。有关患 T1D 风险的信息难以传达，这从该样本中报告的风险感知范围广泛可以看出。
