Mansız-Kaplan Başak, Kotanoğlu Mustafa Sırrı, Gürsoy Koray, Vural Seçil, Koca Gökhan, Nacır Barış, Yumuşak Nihat, Kara Halil, Yüksel Selcen, Korkmaz Meliha
Department of Ergotherapy, Ankara Medipol University, School of Health Sciences, Ankara, Türkiye.
Department of Anesthesiology and Reanimation, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Türkiye.
Turk J Phys Med Rehabil. 2023 Jun 11;69(3):334-343. doi: 10.5606/tftrd.2023.11002. eCollection 2023 Sep.
This study aims to investigate the electrophysiological, scintigraphic, and histopathological effects of pitavastatin and its impact on functional status in rats with sciatic nerve injury.
A total of 30 Wistar albino rats were divided into three equal groups including 10 rats in each group: sham group (no injury), control group (nerve injury induced), and pitavastatin group (nerve injury induced and 2 mg/kg of pitavastatin administered orally once a day for 21 days). Before and at the end of intervention, quantitative gait analysis with the CatWalk system and sciatic nerve conduction studies were performed. After the intervention, the gastrocnemius muscle was scintigraphically evaluated, and the sciatic nerve was histopathologically examined.
There was no significant difference in the sciatic nerve conduction before the intervention and Day 21 among the groups (p>0.05). According to the quantitative gait analysis, there were significant differences in the control group in terms of the individual, static, dynamic, and coordination parameters (p<0.05). The histopathological examination revealed a significant difference in the total myelinated axon count and mean axon diameter among the groups (p<0.001).
Pitavastatin is effective in nerve regeneration and motor function recovery in rats with sciatic nerve injury.
本研究旨在探讨匹伐他汀对坐骨神经损伤大鼠的电生理、闪烁扫描及组织病理学影响，及其对功能状态的作用。
将30只Wistar白化大鼠平均分为三组，每组10只：假手术组（无损伤）、对照组（诱导神经损伤）和匹伐他汀组（诱导神经损伤并每天口服2mg/kg匹伐他汀，持续21天）。在干预前及干预结束时，使用CatWalk系统进行定量步态分析并进行坐骨神经传导研究。干预后，对腓肠肌进行闪烁扫描评估，并对坐骨神经进行组织病理学检查。
干预前与第21天，各组间坐骨神经传导无显著差异（p>0.05）。根据定量步态分析，对照组在个体、静态、动态和协调参数方面存在显著差异（p<0.05）。组织病理学检查显示，各组间有髓轴突总数和平均轴突直径存在显著差异（p<0.001）。
匹伐他汀对坐骨神经损伤大鼠的神经再生和运动功能恢复有效。
