Huang Yanfeng, Lin Qing, Tan Xue, Jia Liangliang, Li Hui, Zhu Zaishi, Fu Changlong, Wang Lili, Liu Linlong, Mao Min, Yi Zhouping, Ma Dezun, Li Xihai
Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.
Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fuzhou, 350122, China.
Heliyon. 2023 Aug 22;9(9):e19322. doi: 10.1016/j.heliyon.2023.e19322. eCollection 2023 Sep.
Osteoarthritis (OA) is a common joint disease characterized by chronic pain, and the perception of pain is closely associated with brain function and neuropeptide regulation. is common plant herb with anti-inflammatory and analgesic properties that is used to treat OA. However, it is unclear whether alleviates OA-related pain via regulation of neuropeptides and brain function. We examined the pain relief regulatory pathway in OA after treatment with by verifying the therapeutic effect of alcohol extract in vivo and vitro and exploring of the potential mechanism underlying the analgesic effect of using functional magnetic resonance imaging and measuring neuropeptide secretion. Our results showed that a alcohol extract and the related active ingredient, , can delay cartilage degradation and alleviate inflammation in OA rats. The a alcohol extract can also relieve OA pain, reduce the secretion of calcitonin gene-related peptide (CGRP) and substance P (SP), and reverse the pathological changes in the cerebral cortex and hippocampus. Our research results demonstrate that alleviates OA pain by protecting cartilage, preventing the stimulation of inflammatory factors on neuropeptide secretion, and influencing the relevant functional areas of the brain.
骨关节炎（OA）是一种以慢性疼痛为特征的常见关节疾病，而疼痛感知与脑功能和神经肽调节密切相关。[某种植物名称]是一种具有抗炎和镇痛特性的常见植物药草，用于治疗OA。然而，尚不清楚[该植物名称]是否通过调节神经肽和脑功能来减轻OA相关疼痛。我们通过在体内和体外验证[该植物名称]醇提取物的治疗效果，并使用功能磁共振成像和测量神经肽分泌来探索[该植物名称]镇痛作用的潜在机制，研究了[该植物名称]治疗后OA中的疼痛缓解调节途径。我们的结果表明，[该植物名称]醇提取物及其相关活性成分[具体成分名称]可以延缓OA大鼠的软骨降解并减轻炎症。[该植物名称]醇提取物还可以缓解OA疼痛，减少降钙素基因相关肽（CGRP）和P物质（SP）的分泌，并逆转大脑皮层和海马体的病理变化。我们的研究结果表明，[该植物名称]通过保护软骨、防止炎症因子对神经肽分泌的刺激以及影响大脑的相关功能区域来减轻OA疼痛。
