Gisslander Karl, de Boer Raïssa, Ingvar Christian, Turesson Carl, Isaksson Karolin, Jayne David, Mohammad Aladdin J
Rheumatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Surgery, Department of Clinical Sciences, Lund University, Lund, Sweden.
Rheumatol Adv Pract. 2023 Aug 18;7(3):rkad071. doi: 10.1093/rap/rkad071. eCollection 2023.
To study if active sun exposure among women affects the risk of developing GCA or PMR in a prospective cohort study with restricted latitudinal variability.
We linked the response to questions relating to sun exposure from the Melanoma Inquiry in Southern Sweden (MISS) prospective cohort study in women to the risk of developing GCA or PMR. Healthcare data were gathered from the Skåne Healthcare Register (SHR), covering all public healthcare consultations. The direct effect of active sun exposure on the risk of developing GCA or PMR was assessed using Cox proportional hazards models adjusted for covariates based on a directed acyclic graph.
A total of 14 574 women were included in the study; 601 women were diagnosed with GCA or PMR (144 and 457, respectively) during the follow-up time. Women with moderate or high sun exposure were not less likely to develop GCA or PMR compared with women that indicated they avoided sun exposure [hazard ratio (HR) 1.2 (CI 0.9, 1.6) and 1.3 (0.9, 1.9), respectively] when adjusted for diabetes, hyperlipidaemia, hypertension, smoking, obesity and stratified by age. Similar patterns were observed when studying only GCA [HR 1.2 (CI 0.7, 2.3) and 1.3 (0.7, 2.6)] and only PMR [HR 1.3 (CI 0.9, 1.8) and 1.4 (0.9, 2.0)].
Active sun exposure did not affect the risk of developing GCA or PMR in women in a cohort with restricted latitudinal variability.
在一项纬度变异性受限的前瞻性队列研究中，探讨女性主动暴露于阳光下是否会影响患巨细胞动脉炎（GCA）或多发性肌炎（PMR）的风险。
我们将瑞典南部黑色素瘤调查（MISS）前瞻性队列研究中女性对阳光暴露相关问题的回答与患GCA或PMR的风险联系起来。医疗保健数据来自斯科讷医疗保健登记处（SHR），涵盖所有公共医疗咨询。基于有向无环图，使用调整协变量的Cox比例风险模型评估主动阳光暴露对患GCA或PMR风险的直接影响。
共有14574名女性纳入研究；随访期间，601名女性被诊断为GCA或PMR（分别为144名和457名）。在调整糖尿病、高脂血症、高血压、吸烟、肥胖并按年龄分层后，与表示避免阳光暴露的女性相比，中度或高度阳光暴露的女性患GCA或PMR的可能性并不更低[风险比（HR）分别为1.2（95%置信区间[CI]0.9，1.6）和1.3（0.9，1.9）]。仅研究GCA[HR 1.2（CI 0.7，2.3）和1.3（0.7，2.6）]和仅研究PMR[HR 1.3（CI 0.9，1.8）和1.4（0.9，2.0）]时观察到类似模式。
在纬度变异性受限的队列中，主动阳光暴露并未影响女性患GCA或PMR的风险。
