Wali F A
Arch Int Pharmacodyn Ther. 1986 Aug;282(2):314-27.
The effect of angiotensin II (AII) on neuromuscular transmission and muscle contraction was investigated by analyzing its effect on electrically-evoked twitch and tetanic contractions in response to motor nerve stimulation at 0.2 Hz and 20 Hz, respectively, the amplitude and duration of frog sciatic nerve compound action potential (NCAP), the uptake (and release) of 3H-methylcholine into/by the nerve-muscle preparation, and the contractures produced by depolarizing agents, e.g. acetylcholine (ACh) and tetraethylammonium (TEA) in the chick, frog and rat skeletal muscle. The results showed that AII, in low concentrations (0.1-10 nM), may facilitate neuromuscular transmission by increasing the amplitudes of indirectly-elicited twitch and tetanic contractions, by increasing the uptake of 3H-methylcholine, and by increasing the duration of the frog NCAP, by about 86%. In high concentrations (greater than 1 microM), AII had inhibitory effects on neuromuscular transmission and produced a small contracture on its own in the muscle (0.4 +/- 0.01 g of tension, n = 6).
通过分别分析血管紧张素II（AII）对0.2 Hz和20 Hz运动神经刺激所引发的电诱发单收缩和强直收缩的影响、蛙坐骨神经复合动作电位（NCAP）的幅度和持续时间、3H-甲基胆碱在神经-肌肉标本中的摄取（和释放），以及去极化剂（如乙酰胆碱（ACh）和四乙铵（TEA））在鸡、蛙和大鼠骨骼肌中所引发的挛缩，研究了AII对神经肌肉传递和肌肉收缩的影响。结果表明，低浓度（0.1 - 10 nM）的AII可通过增加间接诱发的单收缩和强直收缩的幅度、增加3H-甲基胆碱的摄取以及使蛙NCAP的持续时间增加约86%来促进神经肌肉传递。高浓度（大于1 μM）的AII对神经肌肉传递有抑制作用，并在肌肉中自身产生小的挛缩（张力为0.4 ± 0.01 g，n = 6）。
