Fantuz M, Milani R, Andriuoli G, Mastacchi R, Barbanti M
Arch Int Pharmacodyn Ther. 1986 Aug;282(2):328-34.
The aim of this study was to compare the antithrombotic and haemorrhagic effects of unfractionated heparin and OP/LMWH, a new low molecular weight heparin fragment, after subcutaneous administration in rats. Both heparins showed antithrombotic efficacy in a model of acute venous thrombosis even at 1 mg/kg; furthermore OP/LMWH presented a significantly higher activity in subacute venous thrombosis of the rat. At all the dosages tested OP/LMWH showed a significantly shorter bleeding time in the rat by the "transection" method, compared with unfractionated heparin. This study suggests the possibility of dissociating the antithrombotic and haemorrhagic effects of some heparin fractions.
本研究的目的是比较普通肝素与一种新型低分子量肝素片段OP/LMWH在大鼠皮下给药后的抗血栓形成和出血作用。两种肝素在急性静脉血栓形成模型中即使在1mg/kg剂量时也显示出抗血栓形成功效；此外，OP/LMWH在大鼠亚急性静脉血栓形成中表现出显著更高的活性。与普通肝素相比，在所有测试剂量下，通过“横切”法测定，OP/LMWH在大鼠体内的出血时间显著缩短。本研究提示了某些肝素片段的抗血栓形成和出血作用可能分离的可能性。
