Butt W, Auldist A, McDougall P, Duncan A
Aust Paediatr J. 1986 Aug;22(3):221-3. doi: 10.1111/j.1440-1754.1986.tb00227.x.
Tolazoline Hydrochloride is a pulmonary vasodilator that is used for the treatment of pulmonary hypertension of the newborn. Two patients who were receiving Tolazoline by infusion developed duodenal ulceration and subsequent intestinal perforation. This undesirable side effect of Tolazoline may be prevented by the concomitant use of antacids to maintain gastric pH greater than 5.
盐酸妥拉唑啉是一种肺血管扩张剂，用于治疗新生儿肺动脉高压。两名接受妥拉唑啉静脉输注的患者出现十二指肠溃疡并随后发生肠穿孔。通过同时使用抗酸剂使胃pH值维持在大于5，可以预防妥拉唑啉的这种不良副作用。
