Center for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital, Kumamoto, Japan.
Department of Rehabilitation Medicine, Tokyo Women's Medical University Hospital, Japan.
Clin Nutr. 2023 Oct;42(10):2051-2057. doi: 10.1016/j.clnu.2023.08.018. Epub 2023 Aug 30.
BACKGROUND & AIMS: Evidence is limited concerning the association between bioimpedance analysis-derived phase angle and sarcopenic obesity. This study examined this association in patients who underwent convalescent rehabilitation after stroke.
This cross-sectional study included hospitalized patients with post-acute stroke. The phase angle was measured using a multifrequency bioimpedance analysis. Sarcopenic obesity was diagnosed according to the European Society of Clinical Nutrition and Metabolism/European Association for the Study of Obesity criteria. A multiple linear regression analysis was used to examine the association between the phase angle and sarcopenic obesity after adjusting for confounding factors. A receiver operating characteristic curve was used to calculate the optimal phase angle cutoff value for predicting sarcopenic obesity.
A total of 760 patients (median age 71 years; 352 women) were analyzed. The median (interquartile range, 25th and 75th percentiles) phase angle was 4.45° (4.10°, 4.88°). Sarcopenic obesity was diagnosed in 16 (3.9%) men, 18 (5.1%) women, and 34 (4.5%) patients overall. The multiple linear regression analysis showed that sarcopenic obesity (β = -0.185, p = 0.017) and sarcopenia (β = -0.121, p = 0.012) were significantly and negatively associated with the phase angle. Obesity was not significantly associated with the phase angle (β = -0.078, p = 0.094). The optimal cutoff value of the phase angle for diagnosing sarcopenic obesity was 4.29° (sensitivity 0.65, specificity 0.80, area under the curve [AUC] 0.79, 95% CI 0.77-0.87, p < 0.001) in men and 3.84° (sensitivity 0.67, specificity 0.84, AUC 0.81, 95% CI 0.79-0.86, p < 0.001) in women.
The phase angle was associated with sarcopenic obesity, and the cutoff values of the phase angle that could predict sarcopenic obesity were 4.29° for men and 3.84° for women. This simple and practical phase angle-based prediction of sarcopenic obesity can be useful in clinical practice.
生物电阻抗分析得出的相位角与肌少症性肥胖之间的关联证据有限。本研究旨在探讨接受脑卒中后康復治疗的患者中这种关联。
这是一项横断面研究，纳入了住院的急性脑卒中后患者。使用多频生物电阻抗分析测量相位角。根据欧洲临床营养与代谢学会/欧洲肥胖研究协会的标准诊断肌少症性肥胖。调整混杂因素后，采用多元线性回归分析探讨相位角与肌少症性肥胖之间的关联。采用受试者工作特征曲线计算预测肌少症性肥胖的最佳相位角截断值。
共分析了 760 例患者（中位年龄 71 岁；352 例女性）。相位角的中位数（四分位距，25 分位数和 75 分位数）为 4.45°（4.10°，4.88°）。男性中诊断为肌少症性肥胖的有 16 例（3.9%），女性中诊断为肌少症性肥胖的有 18 例（5.1%），总体上有 34 例（4.5%）患者。多元线性回归分析显示，肌少症性肥胖（β=-0.185，p=0.017）和肌少症（β=-0.121，p=0.012）与相位角显著负相关。肥胖与相位角无显著相关性（β=-0.078，p=0.094）。男性中诊断肌少症性肥胖的最佳相位角截断值为 4.29°（灵敏度 0.65，特异性 0.80，曲线下面积 [AUC] 0.79，95%CI 0.77-0.87，p<0.001），女性中为 3.84°（灵敏度 0.67，特异性 0.84，AUC 0.81，95%CI 0.79-0.86，p<0.001）。
相位角与肌少症性肥胖相关，可预测肌少症性肥胖的相位角截断值为男性 4.29°，女性 3.84°。这种简单实用的基于相位角的肌少症性肥胖预测方法在临床实践中可能有用。
