Araujo-Duran Jorge, Kopac Orkun, Montalvo Campana Mateo, Bakal Omer, Sessler Daniel I, Hofstra Richard L, Shah Karan, Turan Alparslan, Ayad Sabry
From the Department of Outcomes Research.
Department of Quantitative Health Sciences.
Anesth Analg. 2024 Apr 1;138(4):751-759. doi: 10.1213/ANE.0000000000006642. Epub 2023 Sep 6.
Relaxation and distraction provided by virtual reality presentations might be analgesic and reduce the need for opioid analgesia. We tested the hypothesis that a virtual reality program (AppliedVR) decreases acute postoperative pain and opioid requirements in patients recovering from hip arthroplasty. We also evaluated whether virtual reality distraction improves patient mobility and reduces the need for antiemetics.
We evaluated 106 adults who were recovering from elective primary total hip arthroplasty. Participating patients were randomized to 2- to 8-minute-long 3-dimensional immersive virtual reality relaxation and distraction video presentations (eg, guided breathing exercises, games, mindfulness) or to 2-dimensional presentations of nature short films (eg, forest wildlife) with neutral music that was chosen to be neither overly relaxing nor distracting, presented through identical headsets. Our primary outcome was pain after virtual reality or sham video presentations, adjusted for pretreatment scores. Secondary outcomes included total opioid consumption, pain scores obtained per routine by nurse staff, perception of video system usability, and pain 1 week after hospital discharge.
Fifty-two patients were randomized to virtual reality distraction and relaxation, and 54 were assigned to 2-dimensional sham presentations. Virtual reality presentations were not found to affect pain scores before and after presentations, with an estimated difference in means (virtual reality minus sham video) of -0.1 points (95% confidence interval [CI], -0.5 to 0.2; P = .391) on a 0 to 10 scale, with 10 being the worst. The mean (standard error [SE]) after-intervention pain score was estimated to be 3.4 (0.3) in the virtual reality group and 3.5 (0.2) in the reference group. Virtual reality treatment was not found to affect postoperative opioid consumption in morphine milligram equivalents, with an estimated ratio of geometric means (virtual reality/sham video) of 1.2 (95% CI, 0.6-2.1; P = .608). Virtual reality presentations were not found to reduce pain scores collected every 4 hours by nursing staff, with an estimated difference in means of 0.1 points (95% CI, -0.9 to 0.7; P = .768).
We did not observe statistically significant or clinically meaningful reductions in average pain scores or opioid consumption. As used in our trial, virtual reality did not reduce acute postoperative pain.
虚拟现实展示所提供的放松和注意力分散可能具有止痛作用,并减少对阿片类药物止痛的需求。我们检验了这样一个假设,即虚拟现实程序(AppliedVR)可降低髋关节置换术后患者的急性术后疼痛及阿片类药物需求量。我们还评估了虚拟现实分散注意力是否能改善患者的活动能力并减少对止吐药的需求。
我们评估了106例接受择期初次全髋关节置换术且正在康复的成年人。参与研究的患者被随机分为两组,一组观看时长2至8分钟的三维沉浸式虚拟现实放松和注意力分散视频展示(如引导式呼吸练习、游戏、正念训练),另一组观看二维自然短片(如森林野生动物)并配以被选为既不过于放松也不分散注意力的中性音乐,两组均通过相同的头戴式设备观看。我们的主要结局是虚拟现实或假视频展示后的疼痛情况,并根据预处理分数进行调整。次要结局包括阿片类药物的总消耗量、护士按常规获取的疼痛评分、对视频系统可用性的感知以及出院后1周的疼痛情况。
52例患者被随机分配至虚拟现实分散注意力和放松组,54例被分配至二维假展示组。未发现虚拟现实展示会影响展示前后的疼痛评分,在0至10分的评分量表上(10分为最严重),平均差值(虚拟现实减去假视频)估计为-0.1分(95%置信区间[CI],-0.5至0.2;P = 0.391)。虚拟现实组干预后的平均(标准误[SE])疼痛评分为3.4(0.3),参照组为3.5(0.2)。未发现虚拟现实治疗会影响以吗啡毫克当量计算的术后阿片类药物消耗量,几何平均数的估计比值(虚拟现实/假视频)为1.2(95% CI,0.6 - 2.1;P = 0.608)。未发现虚拟现实展示能降低护士每4小时收集的疼痛评分,平均差值估计为0.1分(95% CI,-0.9至0.7;P = 0.768)。
我们未观察到平均疼痛评分或阿片类药物消耗量在统计学上有显著降低或具有临床意义的降低。在我们的试验中,虚拟现实并未减轻急性术后疼痛。