Department of Vascular Surgery, The Third Xiangya Hospital of Central South University, Changsha, China.
Central South University Xiangya School of Medicine, Changsha, China.
J Diabetes. 2023 Nov;15(11):955-967. doi: 10.1111/1753-0407.13474. Epub 2023 Sep 7.
The difficulty of wound healing in diabetes mellitus has long been regarded as a thorny problem in the medical field. One of the important reasons is the abnormal function of wound-related cells. A large number of recent studies have shown that microRNA (miR), a noncoding RNA that exists in eukaryotic cells, is closely linked to the functions of various cells in diabetic wound, and ultimately affects the healing of wound. This paper establishes for the first time the connection between miR and wound healing from the cellular perspective and summarizes the effects of various miRs on one or more kinds of wound cells, including their targets and related mechanisms. The abnormal expression of miRs in the wound has certain value for the early diagnosis of diabetic wounds. Moreover, it seems that correcting miRs that are abnormal expressed in the wound or artificially adding miRs that can promote wound healing has an essential therapeutic value.
糖尿病患者的伤口愈合困难一直被视为医学领域的一个棘手问题。其中一个重要原因是与伤口相关的细胞功能异常。大量的最新研究表明，微小 RNA（miR）作为真核细胞中存在的一种非编码 RNA，与糖尿病伤口中各种细胞的功能密切相关，并最终影响伤口的愈合。本文首次从细胞角度建立了 miR 与伤口愈合之间的联系，并总结了各种 miR 对一种或多种伤口细胞的影响，包括它们的靶标和相关机制。miR 在伤口中的异常表达对糖尿病伤口的早期诊断具有一定的价值。此外，纠正伤口中异常表达的 miR 或人为添加可促进伤口愈合的 miR 似乎具有重要的治疗价值。
