Department of Emergency Medicine, Boston Medical Center, Boston, Massachusetts.
Department of Emergency Medicine, Boston Medical Center, Boston, Massachusetts.
J Emerg Med. 2023 Oct;65(4):e272-e279. doi: 10.1016/j.jemermed.2023.05.010. Epub 2023 Jun 9.
Procedural sedation is commonly practiced by emergency physicians to facilitate patient care in the emergency department (ED). Although various guidelines have modernized our approach to procedural sedation, many procedural sedation guidelines and practices still often require that patients be discharged into the care of a responsible adult.
Such requirement for discharge often cannot be met by underserved and undomiciled patients. Benzodiazepines, opioids, propofol, ketamine, "ketofol," etomidate, and methohexital have all been utilized for procedural sedation in the ED. For patients who may require discharge without the presence of an accompanying responsible adult, ketamine, propofol, methohexital, "ketofol," and etomidate are ideal agents for procedural sedation given rapid onsets, short durations of action, and rapid recovery times in patients without renal or hepatic impairment. Proper pre- and postprocedure protocols should be utilized when performing procedural sedation to ensure patient safety. Through the use of appropriate medications and observation protocols, patients can safely be discharged 2 to 4 h postprocedure.
There is no pharmacodynamic or pharmacokinetic basis to require discharge in the care of a responsible adult after procedural sedation. Thoughtful medication selection and the use of evidence-based pre- and postprocedure protocols in the ED can help circumvent this requirement, which likely disproportionally impacts patients who are of low socioeconomic status or undomiciled.
在急诊科(ED)中,程序镇静已被急诊医师广泛应用于促进患者护理。尽管各种指南已经使我们对程序镇静的方法现代化,但许多程序镇静指南和实践仍然常常要求患者出院后由负责的成年人照顾。
对于服务不足和无家可归的患者来说,这种出院要求往往无法得到满足。苯二氮䓬类、阿片类药物、丙泊酚、氯胺酮、“氯胺酮-丙泊酚合剂”、依托咪酯和甲己炔巴比妥都已在 ED 中用于程序镇静。对于可能需要在没有陪同负责成年人的情况下出院的患者,氯胺酮、丙泊酚、甲己炔巴比妥、“氯胺酮-丙泊酚合剂”和依托咪酯是理想的镇静药物,因为它们在肾功能或肝功能正常的患者中起效迅速、作用持续时间短且恢复时间快。在进行程序镇静时,应使用适当的术前和术后方案,以确保患者安全。通过使用适当的药物和观察方案,患者可以在术后 2 至 4 小时安全出院。
在进行程序镇静后,没有药效学或药代动力学的依据要求患者由负责的成年人照顾。在 ED 中,明智地选择药物并使用基于证据的术前和术后方案,可以帮助规避这一要求,这可能会不成比例地影响到社会经济地位较低或无家可归的患者。